Evidence map›Paper›PMID 38114855›Full record

ArticleGeroScience2024

Recapitulation of anti-aging phenotypes by global overexpression of PTEN in mice.

Mary Hager, Peter Chang, Michael Lee, Calvin M Burns, S Joseph Endicott, Richard A Miller, Xinna Li

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in GeroScience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 12 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Article
  6. Review
  7. Oncogenic activation ofGenes & diseases · 2025
    Review
  8. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Mary HagerCollege of Literature, Sciences, & the Arts, University of Michigan, Ann Arbor, MI, 48109, USA.
Peter ChangCollege of Literature, Sciences, & the Arts, University of Michigan, Ann Arbor, MI, 48109, USA.
Michael LeeCollege of Literature, Sciences, & the Arts, University of Michigan, Ann Arbor, MI, 48109, USA.
Calvin M BurnsDepartment of Pathology, University of Michigan School of Medicine, Room 3160, BSRB ,109 Zina Pitcher Place, Ann Arbor, MI, 48109-2200, USA.
S Joseph EndicottDepartment of Pathology, University of Michigan School of Medicine, Room 3160, BSRB ,109 Zina Pitcher Place, Ann Arbor, MI, 48109-2200, USA.
Richard A MillerDepartment of Pathology, University of Michigan School of Medicine, Room 3160, BSRB ,109 Zina Pitcher Place, Ann Arbor, MI, 48109-2200, USA.
Xinna LiDepartment of Pathology, University of Michigan School of Medicine, Room 3160, BSRB ,109 Zina Pitcher Place, Ann Arbor, MI, 48109-2200, USA. xinna@umich.edu.ORCID 0000-0002-7461-5628
University of Michigan · US

Funding

Systems BiologyU19AG023122 · NIA · TRANSLATIONAL GENOMICS RESEARCH INST · PI NICHOLAS Joseph SCHORK · 2004 to 2026
$102.6M
Research Education CoreP30AG024824 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Neil Alexander · 2004 to 2026
$29.2M
Laboratory for Anti-Geric Testing, Evaluation and ResearchU01AG022303 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI RICHARD A MILLER · 2003 to 2026
$25.4M
Integrative Omics to enhance therapeutics development for healthy agingUH3AG064706 · NIA · TRANSLATIONAL GENOMICS RESEARCH INST · PI MILLER, RICHARD A, SCHORK, NICHOLAS JOSEPH · 2021 to 2024
$3.3M
NIA NIH HHS AG023122NIA NIH HHS AG024824NIA NIH HHS P30 AG024824NIA NIH HHS U01 AG022303NIA NIH HHS U19 AG023122NIA NIH HHS UH3 AG064706
6 · The paper itself

Abstract

The PTEN gene negatively regulates the oncogenic PI3K-AKT pathway by encoding a lipid and protein phosphatase that dephosphorylates lipid phosphatidylinositol-3,4,5-triphosphate (PIP

Indexed as

Phosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktAgingAnimalsFibronectinsLipidsMicePhenotypePTEN PhosphohydrolaseFibronectinsFNDC5 protein, mouseLipidsPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktPTEN PhosphohydrolasePten protein, mouseAdipose tissueAgingBrain-derived neurotrophic factor (BDNF)Doublecortin (DCX))Fibronectin type III domain-containing protein 5 (FNDC5)/IRISINGlycosylphosphatidylinositol-specific phospholipase D1 (GPLD1)HippocampusLiverMacrophagePhosphatase and tensin homolog (PTEN)Slow-aging miceUncoupling protein 1 (UCP1)

Identifiers

PMID38114855
PMCPMC10828233
OpenAlexW4389941192

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.