Evidence map›Paper›PMID 38114816›Full record

ArticleNature chemistry2024

Molecular jackhammers eradicate cancer cells by vibronic-driven action.

Ciceron Ayala-Orozco, Diego Galvez-Aranda, Arnoldo Corona, Jorge M Seminario, Roberto Rangel, Jeffrey N Myers, James M Tour

Abstract read
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In one paragraph

Article in Nature chemistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

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  14. FeNanomaterials (Basel, Switzerland) · 2024
    Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ciceron Ayala-OrozcoDepartment of Chemistry, Rice University, Houston, TX, USA. ca5@rice.edu.ORCID 0000-0002-2574-0860
Diego Galvez-ArandaDepartment of Chemical Engineering and Department of Electrical and Computer Engineering, Texas A&M University, College Station, TX, USA.
Arnoldo CoronaDepartment of Head and Neck Surgery, Division of Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Jorge M SeminarioDepartment of Chemical Engineering and Department of Electrical and Computer Engineering, Texas A&M University, College Station, TX, USA. seminario@tamu.edu.ORCID 0000-0001-5397-9281
Roberto RangelDepartment of Head and Neck Surgery, Division of Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.ORCID 0000-0002-9088-7957
Jeffrey N MyersDepartment of Head and Neck Surgery, Division of Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. jmyers@mdanderson.org.ORCID 0000-0003-4767-3408
James M TourDepartment of Chemistry, Rice University, Houston, TX, USA. tour@rice.edu.ORCID 0000-0002-8479-9328

Funding

Welch Foundation C-2017-20220330
6 · The paper itself

Abstract

Through the actuation of vibronic modes in cell-membrane-associated aminocyanines, using near-infrared light, a distinct type of molecular mechanical action can be exploited to rapidly kill cells by necrosis. Vibronic-driven action (VDA) is distinct from both photodynamic therapy and photothermal therapy as its mechanical effect on the cell membrane is not abrogated by inhibitors of reactive oxygen species and it does not induce thermal killing. Subpicosecond concerted whole-molecule vibrations of VDA-induced mechanical disruption can be achieved using very low concentrations (500 nM) of aminocyanines or low doses of light (12 J cm

Indexed as

MelanomaPhotochemotherapyAnimalsCell DeathHumansMiceReactive Oxygen SpeciesReactive Oxygen Species

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.