Evidence map›Paper›PMID 38114475›Full record

ArticleTranslational psychiatry2023

Development and validation of a machine learning model using electronic health records to predict trauma- and stressor-related psychiatric disorders after hospitalization with sepsis.

Santiago Papini, Esti Iturralde, Yun Lu, John D Greene, Fernando Barreda, Stacy A Sterling, Vincent X Liu

Open access · goldAbstract read
In one paragraph

Article in Translational psychiatry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.2field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Santiago PapiniDivision of Research, Kaiser Permanente Northern California, Oakland, CA, USA. spapini@hawaii.edu.ORCID 0000-0002-8109-4437
Esti IturraldeDivision of Research, Kaiser Permanente Northern California, Oakland, CA, USA.ORCID 0000-0001-6837-4998
Yun LuDivision of Research, Kaiser Permanente Northern California, Oakland, CA, USA.ORCID 0000-0002-0900-4249
John D GreeneDivision of Research, Kaiser Permanente Northern California, Oakland, CA, USA.ORCID 0000-0002-0859-6828
Fernando BarredaDivision of Research, Kaiser Permanente Northern California, Oakland, CA, USA.
Stacy A SterlingDivision of Research, Kaiser Permanente Northern California, Oakland, CA, USA.ORCID 0000-0002-6987-8423
Vincent X LiuDivision of Research, Kaiser Permanente Northern California, Oakland, CA, USA.
Kaiser Permanente · USUniversity of Hawaiʻi at Mānoa · US

Funding

Identifying pre-sepsis opportunities for early, targeted intervention - Equipment SupplementR35GM128672 · NIGMS · KAISER FOUNDATION RESEARCH INSTITUTE · PI Vincent Liu · 2018 to 2026
$4.3M
Embedded Mental Health Services Postdoctoral Research Training in Health SystemsT32MH125792 · NIMH · HENRY FORD HEALTH SYSTEM · PI Brian Kenneth Ahmedani · 2021 to 2026
$1.6M
Optimizing Care to Prevent Diabetes and Promote Cardiovascular Health Among Younger Adults with Severe Mental IllnessK23MH126078 · NIMH · KAISER FOUNDATION RESEARCH INSTITUTE · PI Esti Iturralde · 2022 to 2026
$1.0M
NIGMS NIH HHS R35 GM128672NIMH NIH HHS K23 MH126078NIMH NIH HHS T32 MH125792
6 · The paper itself

Abstract

A significant minority of individuals develop trauma- and stressor-related disorders (TSRD) after surviving sepsis, a life-threatening immune response to infections. Accurate prediction of risk for TSRD can facilitate targeted early intervention strategies, but many existing models rely on research measures that are impractical to incorporate to standard emergency department workflows. To increase the feasibility of implementation, we developed models that predict TSRD in the year after survival from sepsis using only electronic health records from the hospitalization (n = 217,122 hospitalizations from 2012-2015). The optimal model was evaluated in a temporally independent prospective test sample (n = 128,783 hospitalizations from 2016-2017), where patients in the highest-risk decile accounted for nearly one-third of TSRD cases. Our approach demonstrates that risk for TSRD after sepsis can be stratified without additional assessment burden on clinicians and patients, which increases the likelihood of model implementation in hospital settings.

Indexed as

Mental DisordersSepsisElectronic Health RecordsHospitalizationHumansMachine LearningProspective StudiesRetrospective Studies

Identifiers

PMID38114475
PMCPMC10730505
OpenAlexW4389979652

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.