Evidence map›Paper›PMID 38114437›Full record

ArticleZoological research2024

Cath-KP, a novel peptide derived from frog skin, prevents oxidative stress damage in a Parkinson's disease model.

Huanpeng Lu, Jinwei Chai, Zijian Xu, Jiena Wu, Songzhe He, Hang Liao, Peng Huang, Xiaowen Huang, Xi Chen, Haishan Jiang and 2 more

Open access · diamondAbstract read
In one paragraph

Article in Zoological research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
4.4field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 24 citations in OpenAlex.

  1. Article
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  4. Article
  5. Review
  6. Article
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  10. Review
  11. Tick-Derived Peptide Blocks Potassium Channel TREK-1.International journal of molecular sciences · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 1 country.

Huanpeng LuDepartment of Neurology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, China.
Jinwei ChaiGuangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, Guangdong 510515, China.
Zijian XuDepartment of Neurology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, China.
Jiena WuGuangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, Guangdong 510515, China.
Songzhe HeDepartment of Neurology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, China.
Hang LiaoGuangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, Guangdong 510515, China.
Peng HuangDepartment of Neurology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, China.
Xiaowen HuangDepartment of Dermatology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, China.
Xi ChenDepartment of Neurology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, China.
Haishan JiangDepartment of Neurology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, China.
Shaogang QuDepartment of Neurology, Ganzhou Hospital-Nanfang Hospital, Southern Medical University, Ganzhou, Jiangxi 341001, China.
Xueqing XuGuangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, Guangdong 510515, China. E-mail: Xu2003@smu.edu.cn.
Nanfang Hospital · CNGuangdong Pharmaceutical University · CNGanzhou People's Hospital · CNSouthern Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Parkinson's disease (PD) is a neurodegenerative condition that results in dyskinesia, with oxidative stress playing a pivotal role in its progression. Antioxidant peptides may thus present therapeutic potential for PD. In this study, a novel cathelicidin peptide (Cath-KP; GCSGRFCNLFNNRRPGRLTLIHRPGGDKRTSTGLIYV) was identified from the skin of the Asiatic painted frog (

Indexed as

DyskinesiasNeuroprotective AgentsParkinson Disease1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine1-Methyl-4-phenylpyridiniumAnimalsAntioxidantsCathelicidinsMiceOxidative Stress1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine1-Methyl-4-phenylpyridiniumAntioxidantsCathelicidinsNeuroprotective AgentsCath-KPNeuroprotectionOxidative stressParkinson’s diseasePeptide

Identifiers

PMID38114437
PMCPMC10839659
OpenAlexW4386463275

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.