Evidence map›Paper›PMID 38114355›Full record

Observational studyBritish journal of anaesthesia2024

Association of perioperative plasma concentration of neurofilament light with delirium after cardiac surgery: a nested observational study.

Charles H Brown, Alexander S Kim, Lisa Yanek, Alexandria Lewis, Kaushik Mandal, Lan Le, Jing Tian, Karin J Neufeld, Charles Hogue, Abhay Moghekar

Open access · bronzeAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in British journal of anaesthesia, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 5 pooled it
4.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 5 syntheses or guidelines pooled it, 19 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Charles H BrownDepartment of Anesthesiology & Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA. Electronic address: cbrownv@jhmi.edu.
Alexander S KimJohns Hopkins University School of Medicine, Baltimore, MD, USA; Department of Medicine, Highland Hospital-Alameda Health System, Oakland, CA, USA.
Lisa YanekDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Alexandria LewisDepartment of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Kaushik MandalDepartment of Surgery, Detroit Medical Center, Detroit, MI, USA.
Lan LeDepartment of Anesthesiology & Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA; George Washington University School of Medicine and Health Sciences, Washington DC, USA.
Jing TianDepartment of Biostatistics, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, USA; Emergent Biosolutions Company, Gaithersburg, MD, USA.
Karin J NeufeldDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Department of Psychiatry and Behavioural Neurosciences, Faculty of Health Sciences, McMaster University, ON, Canada.
Charles HogueDepartment of Anesthesiology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Abhay MoghekarDepartment of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Johns Hopkins University · USDetroit Medical Center · USNorthwestern University · US

Funding

Continuous Cerebral Autoregulation Monitoring to Reduce Brain Injury from CardiacR01HL092259 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI HOGUE, CHARLES W · 2009 to 2018
$3.4M
Cerebral Autoregulation in the Cardiac Surgery Intensive Care Unit: Associations with Postoperative Delirium, Cognitive Change, and Biomarkers of Brain InjuryRF1AG072387 · NIA · JOHNS HOPKINS UNIVERSITY · PI BROWN, CHARLES HUGH, GOEDDEL, LEE ANDREW · 2021 to 2021
$1.2M
Monitoring Cerebral Autoregulation in Patients Undergoing Traumatic Hip Fracture Surgery to Improve Postoperative OutcomesK76AG057020 · NIA · JOHNS HOPKINS UNIVERSITY · PI BROWN, CHARLES HUGH · 2017 to 2021
$1.1M
NHLBI NIH HHS R01 HL092259NIA NIH HHS K76 AG057020NIA NIH HHS RF1 AG072387
6 · The paper itself

Abstract

backgroundNeurofilament light is a blood-based biomarker of neuroaxonal injury that can provide insight into perioperative brain vulnerability and injury. Prior studies have suggested that increased baseline and postoperative concentrations of neurofilament light are associated with delirium after noncardiac surgery, but results are inconsistent. Results have not been reported in cardiac surgery patients, who are among those at highest risk for delirium. We hypothesised that perioperative blood concentrations of neurofilament light (both baseline and change from baseline to postoperative day 1) are associated with delirium after cardiac surgery.

methodsThis study was nested in a trial of arterial blood pressure targeting during cardiopulmonary bypass using cerebral autoregulation metrics. Blood concentrations of neurofilament light were measured at baseline and on postoperative day 1. The primary outcome was postoperative delirium. Regression models were used to examine the associations between neurofilament light concentration and delirium and delirium severity, adjusting for age, sex, race, logistic European System for Cardiac Operative Risk Evaluation, bypass duration, and cognition.

resultsDelirium occurred in 44.6% of 175 patients. Baseline neurofilament light concentration was higher in delirious than in non-delirious patients (median 20.7 pg ml

conclusionsBaseline neurofilament light concentration, but not change from baseline to postoperative day 1, was associated with delirium after cardiac surgery.

Indexed as

Cardiac Surgical ProceduresDeliriumBrainHumansIntermediate FilamentsPostoperative ComplicationsProspective Studiesblood biomarkercardiac surgerygeriatricsneurofilament lightpostoperative delirium

Identifiers

PMID38114355
PMCPMC10808824
OpenAlexW4389912468

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.