ArticleInternational journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases2024
Higher platelet counts and platelet factors are associated with a reduction in Plasmodium falciparum parasite density in young Malian children.
Article in International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed, 4 citations in OpenAlex.
- Epidemiological characteristics of Echinococcus granulosus infection in children from some sites in Xinjiang and its association with platelets.BMC infectious diseases · 2026Article
- Preterm Birth and Malaria Susceptibility in Offspring of Uninfected Multigravid Women.JAMA network open · 2025Observational
- Cytomegalovirus reactivation and acute and chronic complications in children with cerebral malaria: a prospective cohort study.Malaria journal · 2025Article
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Authors and funding
19 authors at 3 institutions in 2 countries.
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Abstract
objectivesThe association between thrombocytopenia and parasite density or disease severity is described in numerous studies. In recent years, several studies described the protective role of platelets in directly killing Plasmodium parasites, mediated by platelet factor 4 (PF4) binding to Duffy antigen. This study aimed to evaluate the protective role of platelets in young children who are Duffy antigen-negative, such as those in sub-Saharan Africa.
methodsA zero-inflated negative binomial model was used to relate platelet count and parasite density data collected in a longitudinal birth cohort. Platelet factors were measured by enzyme-linked immunosorbent assay in samples collected from malaria-infected children who participated in a cross-sectional study.
resultsWe described that an increase of 10,000 platelets/μl was associated with a 2.76% reduction in parasite count. Increasing levels of PF4 and CXCL7 levels were also significantly associated with a reduction in parasite count.
conclusionsPlatelets play a protective role in reducing parasite burden in Duffy-negative children, possibly mediated through activation of the innate immune system.
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