Evidence map›Paper›PMID 38113919›Full record

ArticleJournal of dual diagnosis

Associations among Trauma Exposure, Post-Traumatic Stress Symptoms and Alcohol Use in Black/African American Treatment-Seeking Adults.

Dezarie Moskal, Melanie E Bennett, Russell M Marks, Daniel J O Roche

Registry-linked trialOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of dual diagnosis. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02884908 (Pharmacogenetic Treatment With Anti-Glutaminergic Agents for Comorbid PTSD & AUD), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.9field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02884908 phase3completednot on this map

Pharmacogenetic Treatment With Anti-Glutaminergic Agents for Comorbid PTSD & AUD

TypeinterventionalSponsorUniversity of Maryland, BaltimoreRan2017 to 2022Enrolled57ConditionsPTSD, Alcohol Use DisorderArmsPregabalin plus BBCET, Placebo plus BBCET
3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Dezarie MoskalVA Center for Integrated Healthcare, VA Western New York Healthcare System, Buffalo, New York, USA.ORCID 0000-0002-4209-8881
Melanie E BennettVA VISN 5 Mental Illness Research, Education and Clinical Center, Baltimore VA Medical Center, Baltimore, Maryland, USA.
Russell M MarksDepartment of Psychiatry and Human Behavior, Warren Alpert Medical School of Brown University, Providence, Rhode Island, USA.
Daniel J O RocheDepartment of Psychiatry, University of Maryland, Baltimore, Baltimore, Maryland, USA.ORCID 0000-0001-6298-1519
University of Maryland, Baltimore · USBrown University · USVA Western New York Healthcare System · US

Funding

Pharmacogenetic Treatment with Anti-Glutaminergic Agents for Comorbid PTSD & AUDR01AA024760 · NIAAA · UNIVERSITY OF MARYLAND BALTIMORE · PI BENNETT, MELANIE E. · 2016 to 2020
$3.0M
Development of minocycline as a neuroimmune therapy for alcohol use disorderK01AA026005 · NIAAA · UNIVERSITY OF MARYLAND BALTIMORE · PI ROCHE, DANIEL · 2017 to 2021
$925k
NIAAA NIH HHS K01 AA026005NIAAA NIH HHS R01 AA024760
6 · The paper itself

Abstract

objectiveBlack/African American (AA) individuals are a group at risk for co-occurring posttraumatic stress disorder (PTSD) symptoms and alcohol use due to unique cultural and system-level barriers. Although associations between trauma exposure, PTSD symptoms, and alcohol use are well established across various populations, Black/AA individuals are underrepresented in this literature, and related findings in this population are inconclusive. Thus, the goal of this study was to examine the associations among trauma exposure, PTSD symptoms, and alcohol use in a sample of treatment-seeking, Black/AA adults. We hypothesized that trauma exposure and alcohol use would be positively associated and that this relationship would be mediated by PTSD symptoms.

methodsThis study conducted secondary analysis of screening data from a PTSD and alcohol use disorder clinical trial. Participants were 96 Black/AA adults (57.3% male; 2.0% Hispanic;

resultsFindings illustrated a significant positive association between trauma exposure and PTSD symptoms and between PTSD symptoms and drinks per typical drinking day. PTSD symptoms were not significantly associated with number of drinking days. Tests of indirect effects were significant for trauma exposure on drinks per typical drinking day through PTSD symptoms.

conclusionsResults from the test of indirect effects suggest that among Black/AA adults with heavy alcohol use and trauma exposure, trauma exposure is associated with PTSD symptoms, which in turn is associated with quantity of alcohol use. These findings are consistent with research conducted with White/mixed groups and align with tenets of the self-medication model of PTSD-AUD comorbidity. These findings support current practices that highlight the importance of screening for and addressing PTSD and alcohol use in individuals exposed to trauma. Findings from this paper provide initial data on understudied relationships in an underserved sample and several suggestions are made to generate future research and improve clinical care for Black/AA adults. CLINICAL TRIALS REGISTRY NAME: Pharmacogenetic Treatment With Anti-Glutaminergic Agents for Comorbid PTSD & AUD; ClinicalTrials.gov Identifier: NCT02884908.

Indexed as

AlcoholismStress Disorders, Post-TraumaticAdultAlcohol DrinkingBlack or African AmericanComorbidityFemaleHumansMalealcohol useBlack/African Americanpost-traumatic stressself-medicationtrauma

Identifiers

PMID38113919
PMCPMC10842739
OpenAlexW4390016595

What OpenQuestion holds

Textmetadata
LicenceTDM
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.