Evidence map›Paper›PMID 38113871›Full record

ArticleCerebrovascular diseases (Basel, Switzerland)2024

Causal Effect of Lipoprotein-Associated Phospholipase A2 Activity on Ischemic Stroke: A Mendelian Randomization Study.

Yang Zhang, Miaowen Jiang, Yuan Gao, Yi Xu, Yifan Zhou, Di Wu, Chen Zhou, Guiyou Liu, Ming Li, Xunming Ji

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cerebrovascular diseases (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.5field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Yang ZhangDepartment of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China, zy1192268729@163.com.
Miaowen JiangBeijing Institute for Brain Disorders, Capital Medical University, Beijing, China.
Yuan GaoSchool of Instrumentation and Optoelectronic Engineering, Beihang University, Beijing, China.
Yi XuDepartment of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China.
Yifan ZhouBeijing Institute for Brain Disorders, Capital Medical University, Beijing, China.
Di WuChina-America Institute of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China.
Chen ZhouBeijing Institute for Brain Disorders, Capital Medical University, Beijing, China.
Guiyou LiuBeijing Institute for Brain Disorders, Capital Medical University, Beijing, China.
Ming LiChina-America Institute of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China.
Xunming JiChina-America Institute of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China.
Capital Medical University · CNBeihang University · CNChinese Institute for Brain Research · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe relationship between ischemic stroke (IS) and lipoprotein-associated phospholipase A2 (Lp-PLA2) activity is still unclear, and there is a dearth of stratified research on the relationship between Lp-PLA2 activity and different IS subtypes. Therefore, Mendelian randomization (MR) was used in this study to examine the relationship between genetically proxied Lp-PLA2 activity and the risks of IS and its subtypes.

methodsBased on information from a meta-analysis of genome-wide association studies, which included 13,664 European people, five single nucleotide polymorphisms related to Lp-PLA2 activity were chosen as instrumental variables. Summary statistics information about the MEGESTROKE consortium with the European group (40,585 cases and 406,111 controls) include any IS (AIS; n = 34,217), large-artery stroke (LAS; n = 4,373), cardioembolic stroke (CES; n = 7,193), and small-vessel stroke (SVS; n = 5,386). In order to determine the causal relationships between Lp-PLA2 activity and IS as well as its subtypes, the inverse-variance-weighted (IVW) approach was chosen as the primary analysis. Significant estimates were then tested by sensitivity analysis to rule out heterogeneity and pleiotropy.

resultsIVW showed that Lp-PLA2 activity was causally associated with LAS (odds ratio = 3.25, 95% confidence interval = 1.65-6.41, p = 0.0007) but not with other subtypes of stroke. Sensitivity analysis for causal estimates between Lp-PLA2 activity and LAS showed no significant heterogeneity or pleiotropy.

conclusionsThese MR analyses support a causal effect of Lp-PLA2 activity on LAS but not on AIS, CES, or SVS, which suggests that serum Lp-PLA2 activity might be a biomarker for prediction of LAS.

Indexed as

1-Alkyl-2-acetylglycerophosphocholine EsteraseGenetic Predisposition to DiseaseIschemic StrokeCase-Control StudiesGenome-Wide Association StudyGroup VI Phospholipases A2HumansMendelian Randomization AnalysisPhenotypePolymorphism, Single NucleotideRisk AssessmentRisk Factors1-Alkyl-2-acetylglycerophosphocholine EsteraseGroup VI Phospholipases A2PLA2G6 protein, humanPLA2G7 protein, humanIschemic strokeLarge-artery strokeLipoprotein-associated phospholipase A2 activityMendelian randomization studySingle nucleotide polymorphisms

Identifiers

PMID38113871
PMCPMC11446331
OpenAlexW4390016022

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.