Evidence map›Paper›PMID 38113321›Full record

ArticleCirculation. Cardiovascular imaging2023

Utility of Left and Right Ventricular Strain in Arrhythmogenic Right Ventricular Cardiomyopathy: A Prospective Multicenter Registry.

Mayooran Namasivayam, Philippe B Bertrand, Samuel Bernard, Timothy W Churchill, Shaan Khurshid, Frank I Marcus, Luisa Mestroni, Jeffrey E Saffitz, Jeffrey A Towbin, Wojciech Zareba and 3 more

Open access · greenAbstract readMulticenter Study
In one paragraph

Article in Circulation. Cardiovascular imaging, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.8field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. State-of-the-Art in Echocardiographic Strain Imaging of Arrhythmogenic Cardiomyopathy.Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography · 2026
    Review
  3. Article
  4. Article
  5. Review
  6. Review
  7. Article
  8. Cardiovascular imaging research and innovation in 2023.European heart journal. Imaging methods and practice · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 10 institutions in 3 countries.

Mayooran NamasivayamDivision of Cardiology, Massachusetts General Hospital, Harvard Medical School, Boston (M.N., P.B.B., S.B., T.W.C., S.K., M.H.P., D.Y.S.).ORCID 0000-0001-8985-3947
Philippe B BertrandDivision of Cardiology, Massachusetts General Hospital, Harvard Medical School, Boston (M.N., P.B.B., S.B., T.W.C., S.K., M.H.P., D.Y.S.).ORCID 0000-0001-6324-6874
Samuel BernardDivision of Cardiology, Massachusetts General Hospital, Harvard Medical School, Boston (M.N., P.B.B., S.B., T.W.C., S.K., M.H.P., D.Y.S.).
Timothy W ChurchillDivision of Cardiology, Massachusetts General Hospital, Harvard Medical School, Boston (M.N., P.B.B., S.B., T.W.C., S.K., M.H.P., D.Y.S.).ORCID 0000-0002-0215-3049
Shaan KhurshidDivision of Cardiology, Massachusetts General Hospital, Harvard Medical School, Boston (M.N., P.B.B., S.B., T.W.C., S.K., M.H.P., D.Y.S.).ORCID 0000-0002-2840-4539
Frank I MarcusUniversity of Arizona College of Medicine, Tucson (F.I.M.).
Luisa MestroniDivision of Cardiology and Cardiovascular Institute, University of Colorado Anschutz Medical Campus, Aurora (L.M.).ORCID 0000-0003-1116-2286
Jeffrey E SaffitzBeth Israel Deaconess Medical Center, Harvard Medical School, Boston (J.E.S.).ORCID 0000-0001-8568-9457
Jeffrey A TowbinSt. Jude Children's Research Hospital, University of Tennessee Health Science Center, Memphis (J.A.T).ORCID 0000-0002-4182-2786
Wojciech ZarebaUniversity of Rochester Medical Center, NY (W.Z.).ORCID 0000-0003-4146-420X
Michael H PicardDivision of Cardiology, Massachusetts General Hospital, Harvard Medical School, Boston (M.N., P.B.B., S.B., T.W.C., S.K., M.H.P., D.Y.S.).ORCID 0000-0002-9264-3243
Danita Yoerger SanbornDivision of Cardiology, Massachusetts General Hospital, Harvard Medical School, Boston (M.N., P.B.B., S.B., T.W.C., S.K., M.H.P., D.Y.S.).ORCID 0000-0001-6772-9523
North American ARVC Registry
Massachusetts General Hospital · USBeth Israel Deaconess Medical Center · USGeneral Electric (United States) · USHarvard University · USSt. Jude Children's Research Hospital · USTwitter (United States) · USUniversity of Arizona · USUniversity of Colorado Anschutz Medical Campus · USUniversity of Rochester Medical Center · USVictor Chang Cardiac Research Institute · AU

Funding

Colorado Clinical and Translational Sciences InstituteUL1TR001082 · NCATS · UNIVERSITY OF COLORADO DENVER · PI SOKOL, RONALD J. · 2013 to 2017
$48.0M
Genetics, Mechanisms and Clinical Phenotypes of Arrhythmogenic CardiomyopathyR01HL116906 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI MARCUS, FRANK I, MESTRONI, LUISA · 2013 to 2016
$9.2M
Molecular Epidemiology of Dilated CardiomyopathR01HL069071 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI MESTRONI, LUISA · 2002 to 2005
$2.3M
Aortic Dilatation in Endurance Athletes: A Physiologic and Mechanistic StudyK23HL159262 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI Timothy CHURCHILL · 2022 to 2026
$983k
Electrocardiogram-based deep learning and decision analysis to improve atrial fibrillation risk estimationK23HL169839 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI Shaan Khurshid · 2023 to 2026
$860k
American Heart Association-American Stroke Association 17GRNT33670495NCATS NIH HHS UL1 TR001082NHLBI NIH HHS K23 HL159262NHLBI NIH HHS K23 HL169839NHLBI NIH HHS R01 HL069071NHLBI NIH HHS R01 HL116906
6 · The paper itself

Abstract

backgroundImaging evaluation of arrhythmogenic right ventricular cardiomyopathy (ARVC) remains challenging. Myocardial strain assessment by echocardiography is an increasingly utilized technique for detecting subclinical left ventricular (LV) and right ventricular (RV) dysfunction. We aimed to evaluate the diagnostic and prognostic utility of LV and RV strain in ARVC.

methodsPatients with suspected ARVC (n = 109) from a multicenter registry were clinically phenotyped using the 2010 ARVC Revised Task Force Criteria and underwent baseline strain echocardiography. Diagnostic performance of LV and RV strain was evaluated using the area under the receiver operating characteristic curve analysis against the 2010 ARVC Revised Task Force Criteria, and the prognostic value was assessed using the Kaplan-Meier analysis.

resultsMean age was 45.3±14.7 years, and 48% of patients were female. Estimation of RV strain was feasible in 99/109 (91%), and LV strain was feasible in 85/109 (78%) patients. ARVC prevalence by 2010 ARVC Revised Task Force Criteria is 91/109 (83%) and 83/99 (84%) in those with RV strain measurements. RV global longitudinal strain and RV free wall strain had diagnostic area under the receiver operating characteristic curve of 0.76 and 0.77, respectively (both

conclusionsIn a prospective, multicenter registry of ARVC, RV strain assessment added diagnostic value to current echocardiographic criteria by identifying patients who are missed by current echocardiographic criteria yet still fulfill the diagnosis of ARVC. LV strain, by contrast, did not add incremental diagnostic value but was prognostic for identification of high-risk patients.

Indexed as

Arrhythmogenic Right Ventricular DysplasiaVentricular Dysfunction, RightAdultFemaleHumansMaleMiddle AgedMyocardiumProspective StudiesRegistriesVentricular Function, Rightarrhythmogenic right ventricular dysplasiadiagnosisechocardiographyprognosisventricular dysfunction

Identifiers

PMID38113321
PMCPMC10803132
OpenAlexW4389944845

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.