Evidence map›Paper›PMID 38113313›Full record

ArticleAmerican journal of physiology. Lung cellular and molecular physiology2024

Bacterial pneumonia-induced shedding of epithelial heparan sulfate inhibits the bactericidal activity of cathelicidin in a murine model.

Evan P Zehr, Christopher L Erzen, Kaori Oshima, Christophe J Langouet-Astrie, Wells B LaRiviere, Deling Shi, Fuming Zhang, Bruce D McCollister, Samuel L Windham, Alicia N Rizzo and 5 more

Open access · hybridAbstract read
In one paragraph

Article in American journal of physiology. Lung cellular and molecular physiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.0field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. Epithelial Heparan Sulfate PromotesProteoglycan research · 2025
    Article
  4. Mechanisms of lung crosstalk with end organs: scientific session V-ReSPIRE 2025.American journal of physiology. Lung cellular and molecular physiology · 2025
    Review
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 6 institutions in 2 countries.

Evan P ZehrDepartment of Medicine, University of Colorado School of Medicine, Aurora, Colorado, United States.
Christopher L ErzenDepartment of Medicine, University of Colorado School of Medicine, Aurora, Colorado, United States.
Kaori OshimaDepartment of Medicine, University of Colorado School of Medicine, Aurora, Colorado, United States.ORCID 0000-0002-0882-056X
Christophe J Langouet-AstrieDepartment of Medicine, University of Colorado School of Medicine, Aurora, Colorado, United States.
Wells B LaRiviereDepartment of Medicine, University of Colorado School of Medicine, Aurora, Colorado, United States.
Deling ShiDepartment of Chemical and Biological Engineering, Rensselaer Polytechnic Institute, Troy, New York, United States.
Fuming ZhangDepartment of Chemical and Biological Engineering, Rensselaer Polytechnic Institute, Troy, New York, United States.
Bruce D McCollisterDepartment of Medicine, University of Colorado School of Medicine, Aurora, Colorado, United States.
Samuel L WindhamDepartment of Medicine, Washington University School of Medicine, St. Louis, Missouri, United States.
Alicia N RizzoDepartment of Medicine, Massachusetts General Hospital, Boston, Massachusetts, United States.ORCID 0000-0001-9289-4635
Julie A BastaracheDepartment of Medicine, Vanderbilt University, Nashville, Tennessee, United States.ORCID 0000-0003-0458-6507
Alexander R HorswillDepartment of Medicine, University of Colorado School of Medicine, Aurora, Colorado, United States.
Eric P SchmidtDepartment of Medicine, Massachusetts General Hospital, Boston, Massachusetts, United States.ORCID 0000-0002-7360-0504
Jakub M KwiecinskiDepartment of Microbiology, Jagiellonian University, Krakow, Poland.
James F ColbertDepartment of Medicine, University of Colorado School of Medicine, Aurora, Colorado, United States.ORCID 0000-0002-3060-2550
University of Colorado Denver · USMassachusetts General Hospital · USRensselaer Polytechnic Institute · USJagiellonian University · PLVanderbilt University · USWashington University in St. Louis · US

Funding

PRINCIPLES IN PULMONARY RESEARCHT32HL007317 · NHLBI · WASHINGTON UNIVERSITY · PI Steven Brody, Michael J Holtzman · 1985 to 2026
$16.1M
Applying Innovative Lung Mapping Strategies to Understand Alveolar Capillary Barrier Permeability in ARDSR35HL150783 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Julie A. Bastarache · 2020 to 2026
$4.6M
Endothelial glycocalyx reconstitution during sepsisR01HL125371 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI LINHARDT, ROBERT J, SCHMIDT, ERIC PETER · 2014 to 2018
$3.4M
Quorum sensing, diversity and skin inflammationR01AI153185 · NIAID · UNIVERSITY OF COLORADO DENVER · PI GALLO, RICHARD L, HORSWILL, ALEXANDER R · 2020 to 2024
$3.2M
Aging-associated changes in gut microbiome drive sepsis severityK08AG061144 · NIA · UNIVERSITY OF COLORADO DENVER · PI COLBERT, JAMES F · 2019 to 2023
$799k
Epithelial glycocalyx degradation mediates surfactant dysfunction in acute respiratory distress syndromeF32HL162230 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI RIZZO, ALICIA N · 2022 to 2023
$121k
NHLBI NIH HHS F32 HL162230NHLBI NIH HHS R01 HL125371NHLBI NIH HHS R35 HL150783NHLBI NIH HHS T32 HL007317NIAID NIH HHS R01 AI153185NIA NIH HHS K08 AG061144
6 · The paper itself

Abstract

Bacterial pneumonia is a common clinical syndrome leading to significant morbidity and mortality worldwide. In the current study, we investigate a novel, multidirectional relationship between the pulmonary epithelial glycocalyx and antimicrobial peptides in the setting of methicillin-resistant

Indexed as

Methicillin-Resistant Staphylococcus aureusPneumonia, BacterialAnimalsAnti-Bacterial AgentsAntimicrobial Cationic PeptidesCathelicidinsDisease Models, AnimalHeparan SulfateHumansMiceOligosaccharidesAnti-Bacterial AgentsAntimicrobial Cationic PeptidesCathelicidinsHeparan SulfateOligosaccharidesantimicrobial peptidescathelicidinheparan sulfatepneumoniaStaphylococcus aureus

Identifiers

PMID38113313
PMCPMC11280675
OpenAlexW4389944436

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.