ArticleCirculation. Cardiovascular interventions2023
Transcatheter Palliation With Pulmonary Artery Flow Restrictors in Neonates With Congenital Heart Disease: Feasibility, Outcomes, and Comparison With a Historical Hybrid Stage 1 Cohort.
Article in Circulation. Cardiovascular interventions, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.
- Innovations in transcatheter interventions for hypoplastic left heart syndrome and borderline left heart structures from fetal to neonatal life: current evidence and systematic review of recent advances (2016-2025).European journal of pediatrics · 2026Pooled it
- How to evaluate, triage, and sedate a patient in the congenital cardiac catheterization laboratory.Translational pediatrics · 2026Review
- Transcatheter-Based Palliation of Congenital Heart Disease in Very Low Birth Weight Infants.JACC. Case reports · 2026Article
- Outcomes of Modified Microvascular Plugs as a Pulmonary Flow Restrictors in Congenital Heart Disease.Pediatric cardiology · 2026Article
- Fenestrated PECA exGraft Patch as a Novel Modifiable Internal Pulmonary Artery Band: A Case Report.Pediatric cardiology · 2026Article
- Cardiac Interventions in Neonates: State of the Art.Indian journal of pediatrics · 2026Review
- Unconventional Ductal Flow Restriction and Iatrogenic Pseudoaneurysm Plug Closure in Pulmonary Atresia With Intact Septum.JACC. Case reports · 2026Article
- Proposal: Bold New Indications for Transcatheter Pulmonary Flow Restrictors.Pediatric cardiology · 2026Review
- Use of pulmonary artery flow restrictors in neonates with congenital heart disease: Timing and technical considerations.JTCVS structural and endovascular · 2025Article
- Percutaneous Pulmonary Artery Banding in the Low-Weight Term Newborn with Univentricular Heart.Indian journal of pediatrics · 2025Article
- Balloon dilation of the para-device space to alleviate severe flow restriction in an oversized pulmonary flow restrictor: a case report.BMC cardiovascular disorders · 2025Article
- Management of Neonates With Complex Left-Sided Obstructions Using Endovascular Flow Regulators and Ductal Stenting.JACC. Case reports · 2025Article
- Combined Use of a Modified Microvascular Plug Flow Restrictor and Right Ventricular Outflow Tract Stenting.JACC. Case reports · 2025Article
- Updates in interventional cardiology in children with cardiac disease.European journal of pediatrics · 2025Review
- Prenatal diagnosis mediates the relationship between disease complexity and intervention timing for congenital heart defects.Pregnancy (Hoboken, N.J.) · 2025Article
- Surgical removal of pulmonary flow restrictors in children with congenital heart disease: What the outcomes reveal.JTCVS open · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 1 institution in 2 countries.
Funding
Abstract
backgroundNeonates with complex congenital heart disease and pulmonary overcirculation have been historically treated surgically. However, subcohorts may benefit from less invasive procedures. Data on transcatheter palliation are limited.
methodsWe present our experience with pulmonary flow restrictors (PFRs) for palliation of neonates with congenital heart disease, including procedural feasibility, technical details, and outcomes. We then compared our subcohort of high-risk single ventricle neonates palliated with PFRs with a similar historical cohort who underwent a hybrid Stage 1. Cox regression was used to evaluate the association between palliation strategy and 6-month mortality.
resultsFrom 2021 to 2023, 17 patients (median age, 4 days; interquartile range [IQR], 2-8; median weight, 2.5 kilograms [IQR, 2.1-3.3]) underwent a PFR procedure; 15 (88%) had single ventricle physiology; 15 (88%) were high-risk surgical candidates. All procedures were technically successful. At a median follow-up of 6.2 months (IQR, 4.0-10.8), 13 patients (76%) were successfully bridged to surgery (median time since PFR procedure, 2.6 months [IQR, 1.1-4.4]; median weight, 4.9 kilograms [IQR, 3.4-5.8]). Pulmonary arteries grew adequately for age, and devices were easily removed without complications. The all-cause mortality rate before target surgery was 24% (n=4). Compared with the historical hybrid stage 1 cohort (n=23), after adjustment for main confounding (age, weight, intact/severely restrictive atrial septum or left ventricle to coronary fistulae), the PFR procedure was associated with a significantly lower all-cause 6-month mortality risk (adjusted hazard ratio, 0.26 [95% CI, 0.08-0.82]).
conclusionsTranscatheter palliation with PFR is feasible, safe, and represents an effective strategy for bridging high-risk neonates with congenital heart disease to surgical palliation, complete repair, or transplant while allowing for clinical stabilization and somatic growth.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.