Evidence map›Paper›PMID 38113284›Full record

ArticleClinical transplantation2024

Prevalence of cognitive impairment in liver transplant recipients.

Kacey Berry, Jessica M Ruck, Fawzy Barry, Amy M Shui, Aly Cortella, Dorothea Kent, Srilakshmi Seetharaman, Randi Wong, Lawren VandeVrede, Jennifer C Lai

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical transplantation, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Kacey BerryMemory and Aging Center, Department of Neurology, University of California San Francisco, San Francisco, California, USA.ORCID 0000-0001-8422-9379
Jessica M RuckDepartment of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.ORCID 0000-0002-5749-5505
Fawzy BarryDepartment of Medicine, Division of Gastroenterology and Hepatology, University of California San Francisco, San Francisco, California, USA.
Amy M ShuiDepartment of Medicine, Division of Gastroenterology and Hepatology, University of California San Francisco, San Francisco, California, USA.
Aly CortellaDepartment of Medicine, Division of Gastroenterology and Hepatology, University of California San Francisco, San Francisco, California, USA.
Dorothea KentDepartment of Medicine, Division of Gastroenterology and Hepatology, University of California San Francisco, San Francisco, California, USA.
Srilakshmi SeetharamanDepartment of Medicine, Division of Gastroenterology and Hepatology, University of California San Francisco, San Francisco, California, USA.
Randi WongDepartment of Medicine, Division of Gastroenterology and Hepatology, University of California San Francisco, San Francisco, California, USA.
Lawren VandeVredeMemory and Aging Center, Department of Neurology, University of California San Francisco, San Francisco, California, USA.
Jennifer C LaiDepartment of Medicine, Division of Gastroenterology and Hepatology, University of California San Francisco, San Francisco, California, USA.ORCID 0000-0003-2092-6380
University of California, San Francisco · USJohns Hopkins University · US

Funding

UCSF Liver Core CenterP30DK026743 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI James P. Grenert · 1986 to 2026
$30.7M
The spectrum of cognitive impairment including Alzheimer’s Disease and Related Dementias after liver transplantationR01AG059183 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Jennifer C. Lai · 2018 to 2026
$9.9M
Validation of Novel Plasma Biomarkers for Mixed Etiology DementiaK23AG073514 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI VANDEVREDE, LAWREN · 2021 to 2025
$1.0M
The Impact of Frailty on Liver Transplant Outcomes in Older Adults with Hepatocellular CarcinomaK24AG080021 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Jennifer C. Lai · 2023 to 2026
$755k
Frailty and post-liver transplant delirium and cognitive impairment in older recipientsF32AG067642 · NIA · JOHNS HOPKINS UNIVERSITY · PI RUCK, JESSICA MOORE · 2021 to 2023
$258k
NIA NIH HHS F32 AG067642NIA NIH HHS K23 AG073514NIA NIH HHS K24 AG080021NIA NIH HHS L30 AG069301NIA NIH HHS R01 AG059183NIDDK NIH HHS P30 DK026743
6 · The paper itself

Abstract

Liver transplant (LT) recipients have a high burden of cognitive impairment risk factors identified in other populations, yet little work has explored cognition in the United States LT population. We characterized prevalence of cognitive impairment (CI) in LT recipients pre-LT and ≥3 months post-LT. Adult LT recipients with cirrhosis but without active pre-LT hepatic encephalopathy (HE) were screened for CI using the Montreal Cognitive Assessment (MoCA) for CI (MoCA <24) both pre-LT and ≥3 months post-LT. The association between cognitive performance and recipient characteristics was assessed using logistic regression. Of 107 LT recipients, 36% had pre-LT CI and 27% had post-LT CI [median (Q1-Q3) MoCA 26 (23-28)]. Each 1-point increase in pre-LT MoCA was associated with 26% lower odds of post-LT cognitive impairment (aOR .74, 95% CI .63-.87, p < .001), after adjusting for recipient age, history of HE, and time since LT. In this study of cirrhosis recipients without active pre-LT HE, cognitive impairment was prevalent before LT and remained prevalent ≥3 months after LT (27%), long after effects of portal hypertension on cognition would be expected to have resolved. Our data expose an urgent need for more comprehensive neurologic examination of LT recipients to better identify, characterize, and address predictors of post-LT cognitive impairment.

Indexed as

Cognitive DysfunctionLiver TransplantationAdultCognitionHumansLiver CirrhosisPrevalenceUnited StatesAlzheimer'scirrhosiscognitive declinedementiaorgan transplant

Identifiers

PMID38113284
PMCPMC10842727
OpenAlexW4389981755

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.