Evidence map›Paper›PMID 38113233›Full record

ArticlePloS one2023

Differences in the gut microbiota between Gurkhas and soldiers of British origin.

Thomas D Troth, Ross S McInnes, Steven J Dunn, Jeremy Mirza, Annalise H Whittaker, Sarah A Goodchild, Nicholas J Loman, Sarah V Harding, Willem van Schaik

Open access · goldAbstract read
In one paragraph

Article in PloS one, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Thomas D TrothInstitute of Microbiology and Infection, University of Birmingham, Birmingham, United Kingdom.
Ross S McInnesInstitute of Microbiology and Infection, University of Birmingham, Birmingham, United Kingdom.ORCID 0000-0003-3223-6440
Steven J DunnInstitute of Microbiology and Infection, University of Birmingham, Birmingham, United Kingdom.ORCID 0000-0003-1529-6900
Jeremy MirzaInstitute of Microbiology and Infection, University of Birmingham, Birmingham, United Kingdom.
Annalise H WhittakerCBR Division, Defence and Science Technology Laboratory, Salisbury, Wiltshire, United Kingdom.
Sarah A GoodchildCBR Division, Defence and Science Technology Laboratory, Salisbury, Wiltshire, United Kingdom.
Nicholas J LomanInstitute of Microbiology and Infection, University of Birmingham, Birmingham, United Kingdom.
Sarah V HardingCBR Division, Defence and Science Technology Laboratory, Salisbury, Wiltshire, United Kingdom.
Willem van SchaikInstitute of Microbiology and Infection, University of Birmingham, Birmingham, United Kingdom.ORCID 0000-0001-5832-0988
University of Birmingham · GBDefence Science and Technology Laboratory · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Previous work indicated that the incidence of travellers' diarrhoea (TD) is higher in soldiers of British origin, when compared to soldiers of Nepalese descent (Gurkhas). We hypothesise that the composition of the gut microbiota may be a contributing factor in the risk of developing TD in soldiers of British origin. This study aimed to characterise the gut microbial composition of Gurkha and non-Gurkha soldiers of the British Army. Recruitment of 38 soldiers (n = 22 Gurkhas, n = 16 non-Gurkhas) and subsequent stool collection, enabled shotgun metagenomic sequencing-based analysis of the gut microbiota. The microbiota of Gurkhas had significantly (P < 0.05) lower diversity, for both Shannon and Simpson diversity indices, using species level markers than the gut microbiota of non-Gurkha soldiers. Non-metric Multidimensional Scaling (NMDS) of the Bray-Curtis distance matrix revealed a significant difference in the composition of the gut microbiota between Gurkhas and non-Gurkha soldiers, at both the species level (P = 0.0178) and the genus level (P = 0.0483). We found three genera and eight species that were significantly enriched in the non-Gurkha group and one genus (Haemophilus) and one species (Haemophilus parainfluenzae) which were enriched in the Gurkha group. The difference in the microbiota composition between Gurkha soldiers and soldiers of British origin may contribute to higher colonization resistance against diarrhoeal pathogens in the former group. Our findings may enable further studies into interventions that modulate the gut microbiota of soldiers to prevent TD during deployment.

Indexed as

Gastrointestinal MicrobiomeMilitary PersonnelAsian PeopleHumansMetagenomeWhite People

Identifiers

PMID38113233
PMCPMC10729956
OpenAlexW4389978862

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.