ArticleOphthalmology and therapy2024
Subfoveal and Parafoveal Choroidal Thickening in Patients with Keratoconus Using the ETDRS Grid on Swept-Source OCT.
Article in Ophthalmology and therapy, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Evaluation of Microcirculation at the Optic Nerve Head in Eyes With Keratoconus.Investigative ophthalmology & visual science · 2026Article
- Hyperspectral Imaging for the Classification and Analysis of Drusen in Age-Related Macular Degeneration.Investigative ophthalmology & visual science · 2026Observational
- Macular Choroidal Thickness in Keratoconus: Systematic Review and Meta-Analysis of Current Evidence.Diagnostics (Basel, Switzerland) · 2025Review
- Early retinal and choroidal changes in the macula region associated with axial length in myopic children and adolescents based on swept-source OCTA.Frontiers in medicine · 2025Article
- Relationship between Choroidal Thickness and Anterior Scleral Thickness in Patients with Keratoconus.Diagnostics (Basel, Switzerland) · 2024Article
- Posterior segment alterations in keratoconus patients: an updated comprehensive review.Therapeutic advances in ophthalmologyReview
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5 authors.
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Abstract
introductionThere is growing evidence that confirms morphological changes in the posterior structures in patients with keratoconus (KC); however, isolated alterations could have been missed. This study assesses choroidal thickness (CT) in the fovea and beyond in KC eyes.
methodsThis prospective case-control and non-randomized study enrolled 107 eyes, 62 eyes of 62 patients with KC, and 45 age-matched eyes of 45 control subjects with axial length in the range of 22-26 mm. Swept-source optical coherence tomography (SS-OCT) was performed to manually measure the subfoveal choroidal thickness (SCT) using a single-line scan. CT was obtained automatically from the Early Treatment Diabetic Retinopathy Study (ETDRS) grid using the 12-lines radial scan pattern. A two-way repeated-measures analysis of variance (ANOVA) was conducted to evaluate CT variations among macular eccentricity, parafoveal area, and the interaction between both factors. CT was compared in all parafoveal areas between groups and subgroups of KC.
resultsSCT was significantly thicker in KC eyes (357 ± 57 µm) than in healthy eyes (325 ± 63 µm) (p < 0.001). Significant choroidal thickening was observed in the central ring and outer and inner rings of the temporal, superior, and inferior parafoveal macular areas (p < 0.001), except in the outer ring of the nasal macular zone (p > 0.05) of KC compared to healthy eyes. The CT significantly decreased from the center to the outer ring regardless of the presence of KC (p < 0.001). The choroid in the nasal macular zone was significantly thinner than that in the temporal, superior, and inferior parafoveal areas (p < 0.001).
conclusionsThe choroidal structure increased its thickness not only in the subfoveal area, but also in eight parafoveal areas of the ETDRS grid encompassing a wider area of macular examination. These findings demonstrate and corroborate that keratoconus is not a purely corneal disease. Furthermore, it confirms the role that the choroidal structure has in the pathophysiology of keratoconus.
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