ArticleAnalytical sciences : the international journal of the Japan Society for Analytical Chemistry2024
Targeted-activation superparamagnetic spherical nucleic acid nanomachine for ultrasensitive SERS detection of lysozyme based on a bienzymatic-mediated in situ amplification strategy.
Article in Analytical sciences : the international journal of the Japan Society for Analytical Chemistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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5 citing papers in PubMed, 7 citations in OpenAlex.
- Beyond ensemble averages: single-entity approaches for complex systems.Analytical sciences : the international journal of the Japan Society for Analytical Chemistry · 2026Review
- Lysozyme detection in body biofluids by dual-decorated graphene oxide-gold nanoparticles-based biomimetic plasmonic sensor.Mikrochimica acta · 2025Article
- Application of the Chitooligosaccharides and Fluorescence Polarization Technique for the Assay of Active Lysozyme in Hen Egg White.Biomolecules · 2024Article
- Enhancing the sensitivity of immunoassays toward single-cell secretion analysis.Analytical sciences : the international journal of the Japan Society for Analytical Chemistry · 2024Article
- Nanomaterial-based sensors in analytical chemistry.Analytical sciences : the international journal of the Japan Society for Analytical Chemistry · 2024Article
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Authors and funding
10 authors at 1 institution in 1 country.
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Abstract
Lysozyme (LYS) is a widely used bacteriostatic enzyme. In this paper, we built a sensitive and accurate Raman biosensing platform to detect trace amounts of LYS. The method is based on magnetic spherical nucleic acid formed by a combination of LYS aptamer (Apt) and magnetic beads (MBs). Meanwhile, this method utilizes a dual enzyme-assisted nucleic acid amplification circuit and surface-enhanced Raman scattering (SERS). In this sensing strategy, which is based on the specific recognition of Apt, magnetic spherical nucleic acids were associated with SERS through a nucleic acid amplification circuit, and the low abundance of LYS was converted into a high-specificity Raman signal. Satellite-like MB@AuNPs were formed in the presence of the target, which separated specifically in a magnetic field, effectively avoided the interference of complex sample environment. Under the optimal sensing conditions, the concentration of LYS exhibited a good linear relationship between 1.0 × 10
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