ReviewBiometals : an international journal on the role of metal ions in biology, biochemistry, and medicine2024
The good, the bad, and the ugly of metals as antimicrobials.
Review in Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed.
- Pt(II) Rollover Complexes with Poor-Donor Bipyridines: Synthesis, Reactivity, and Preliminary Antimicrobial Evaluation.ACS omega · 2026Article
- Contrasts and similarities in the transcriptomic response to antimicrobial coinage metals inMicrobiology spectrum · 2026Article
- Dinuclear Copper(II) and Molybdenum(VI) Complexes of Bis-Tridentate Hydrazonylthiophene: Synthesis and Biochemical Evaluation.Chemistry & biodiversity · 2026Article
- Antimicrobial Activity of Metal-Based Danofloxacin Complexes Against Pathogenic Microorganisms.Molecules (Basel, Switzerland) · 2026Article
- Assessing non-porous antimicrobial surfaces against bacteria, phages and fungi: a comparative study under varied normative conditions using glass as a benchmark for microbial persistence.BMC microbiology · 2026Article
- Metal-Ligand Interactions: Overlooked Confounders in Antibiotic Discovery and Development.ACS infectious diseases · 2026Article
- Article
- Antibiotic resistance dissemination in soil ecosystems: deep understanding for effective management and global health protection.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2026Review
- Hyperbranched Polymer Dendrimers Embedded in Electrospun Nanofibers for Safe and Sustainable Antibacterial Filtration Materials.Polymers · 2026Article
- Genomic characterization of a virulent multidrug-resistant Salmonella enterica serovar Enteritidis strain isolated from meat rabbits (Oryctolagus cuniculus) in China.BMC microbiology · 2026Article
- Cyclopalladated Complexes With Functionalized Diphosphanes as Promising Antifungal Scaffolds.Bioinorganic chemistry and applications · 2026Article
- Biogenic nanoparticles: overview of challenges in production, characterization and use.Frontiers in chemistry · 2026Review
- Trimetallic Nanocomposites Grafted on Modified PET Substrate Revealing Antibacterial Effect AgainstMolecules (Basel, Switzerland) · 2025Article
- Antimicrobial Biomaterials Based on Composites of Metal Nanoparticles and Plant Extracts.Materials (Basel, Switzerland) · 2025Review
- Antibiotic Resistance Crisis: From Bacterial Bioprospecting to Artificial Intelligence.Environmental microbiology reports · 2025Review
- Dual-responsive copper complex delivered by dissolvable microneedle promotes polymicrobial infection eradication and cutaneous wound healing.Materials today. Bio · 2025Article
- Role of AprA and pyocyanin fromMicrobiology (Reading, England) · 2025Article
- Bacteria Under Metal Stress-Molecular Mechanisms of Metal Tolerance.International journal of molecular sciences · 2025Review
- Preparation and characteristics evaluation of chitosan-coated nanoliposomes containing ferrous sulfate.Scientific reports · 2025Article
- Antimicrobial Activity of Copper(II), Nickel(II) and Zinc(II) Complexes with Semicarbazone and Thiosemicarbazone Ligands Derived from Substituted Salicylaldehydes.Molecules (Basel, Switzerland) · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We are now moving into the antimicrobial resistance (AMR) era where more antibiotic resistant bacteria are now the majority, a problem brought on by both misuse and over use of antibiotics. Unfortunately, the antibiotic development pipeline dwindled away over the past decades as they are not very profitable compounds for companies to develop. Regardless researchers over the past decade have made strides to explore alternative options and out of this we see revisiting historical infection control agents such as toxic metals. From this we now see a field of research exploring the efficacy of metal ions and metal complexes as antimicrobials. Such antimicrobials are delivered in a variety of forms from metal salts, alloys, metal complexes, organometallic compounds, and metal based nanomaterials and gives us the broad term metalloantimicrobials. We now see many effective formulations applied for various applications using metals as antimicrobials that are effective against drug resistant strains. The purpose of the document here is to step aside and begin a conversation on the issues of use of such toxic metal compounds against microbes. This critical opinion mini-review in no way aims to be comprehensive. The goal here is to understand the benefits of metalloantimicrobials, but also to consider strongly the disadvantages of using metals, and what are the potential consequences of misuse and overuse. We need to be conscious of the issues, to see the entire system and affect through a OneHealth vision.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.