Evidence map›Paper›PMID 38112841›Full record

ArticleDigestive diseases and sciences2024

Parental History of Type 2 Diabetes Mellitus and PNPLA3 Polymorphism Increase the Risk of Severe Stages of Nonalcoholic Fatty Liver Disease.

Natalia Balassiano Wajsbrot, Nathalie Carvalho Leite, Paulo Henrique Condeixa Franca, Claudia Regina Lopes Cardoso, Gil Fernando Salles, Cristiane A Villela-Nogueira

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Article in Digestive diseases and sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Review
4 · The record

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5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Natalia Balassiano WajsbrotDivision of Hepatology, Clementino Fraga Filho University Hospital, Federal University of Rio de Janeiro, Rua Professor Rodolpho Paulo Rocco, 255- Cidade Universitária, Rio de Janeiro, RJ, 20941-913, Brazil. nataliabalassiano@yahoo.com.br.ORCID http://orcid.org/0000-0001-5780-4390
Nathalie Carvalho LeiteDivision of Hepatology, Clementino Fraga Filho University Hospital, Federal University of Rio de Janeiro, Rua Professor Rodolpho Paulo Rocco, 255- Cidade Universitária, Rio de Janeiro, RJ, 20941-913, Brazil.
Paulo Henrique Condeixa FrancaPost-Graduation Program On Health and Environment, University of the Region of Joinville (Univille), Santa Catarina, Brazil.
Claudia Regina Lopes CardosoDepartment of Internal Medicine, Medical School, Federal University of Rio de Janeiro, Rio de Janeiro, 20941-913, Brazil.
Gil Fernando SallesDepartment of Internal Medicine, Medical School, Federal University of Rio de Janeiro, Rio de Janeiro, 20941-913, Brazil.
Cristiane A Villela-NogueiraDepartment of Internal Medicine, Medical School, Federal University of Rio de Janeiro, Rio de Janeiro, 20941-913, Brazil.
Universidade Federal do Rio de Janeiro · BRUniversidade da Região de Joinville · BR

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico 311714/2018-8
6 · The paper itself

Abstract

BACKGROUND &

aimsIn non-alcoholic fatty liver disease (NAFLD), the influence of parental history of type 2 diabetes (T2D) allied to single nucleotide polymorphisms (SNPs) in the offspring is not known. We aimed to investigate the impact of the parental history of T2D, PNPLA3 and TM6SF2 polymorphisms in liver steatosis and fibrosis.

methodsThis was a case-control study involving the offspring of T2D patients and controls without a parental history of T2D. Participants underwent clinical and laboratory evaluation, transient elastography (TE) by Fibroscan

results161 T2D offspring and 78 controls, 10-46 years old, were included. The offspring of T2D had higher prevalences of obesity, T2D, arterial hypertension and sedentarism. Parental history of T2D was associated with fibrosis ≥ F2 (OR 8.89, CI 95% 1.09-72.01, p = 0.041) after adjustment for age, gender, metabolic traits and SNPs. PNPLA3 GG genotype was independently associated with steatosis ≥ S1 (OR 8.15, CI 95% 1.93-34.38, p = 0.004) and fibrosis ≥ F2 (OR 4.31, CI 95% 1.11-16.61, p = 0.034).

conclusionsThe offspring of T2D patients present a worse metabolic profile and the parental history of T2D confers an increased likelihood of hepatic fibrosis, independent of metabolic factors. PNPLA3 homozygous GG, but not TM6SF2 genotypes, also impacts on this phenotype.

Indexed as

Diabetes Mellitus, Type 2Non-alcoholic Fatty Liver DiseaseAcyltransferasesAdolescentAdultCase-Control StudiesChildFibrosisGenetic Predisposition to DiseaseGenotypeHumansLiverMiddle AgedPhospholipases A2, Calcium-IndependentPolymorphism, Single NucleotideYoung AdultAcyltransferasesPhospholipases A2, Calcium-IndependentPNPLA3 protein, humanHepatic fibrosisNAFLDOffspringPNPLA3TM6SF2Type 2 diabetes mellitus

Identifiers

PMID38112841
OpenAlexW4389949629

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.