Evidence map›Paper›PMID 38112465›Full record

ArticlemBio2024

TLR4 sensing of IsdB of

Juan José Izquierdo Gonzalez, Md Faruq Hossain, Jolanda Neef, Erin E Zwack, Chih-Ming Tsai, Dina Raafat, Kevin Fechtner, Luise Herzog, Thomas P Kohler, Rabea Schlüter and 10 more

Open access · goldAbstract read
In one paragraph

Article in mBio, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Article
  3. Community-acquired pneumonia withJournal of thoracic disease · 2026
    Article
  4. Article
  5. Heme and immunity: The heme oxygenase dichotomy.Journal of inorganic biochemistry · 2025
    Review
  6. Article
  7. Review
  8. Article
  9. Pathogens (Basel, Switzerland) · 2025
    Review
  10. Article
  11. Review
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 5 institutions in 4 countries.

Juan José Izquierdo GonzalezInstitute of Immunology, University Medicine Greifswald, Greifswald, Germany.
Md Faruq HossainInstitute for Medical Biochemistry and Molecular Biology, University Medicine Greifswald, Greifswald, Germany.
Jolanda NeefDepartment of Medical Microbiology, University of Groningen, University Medical Center, Groningen, the Netherlands.
Erin E ZwackDepartment of Microbiology, New York University Grossman School of Medicine, New York, USA.
Chih-Ming TsaiDepartment of Pediatrics, Division of Infectious Diseases, University of California San Diego, La Jolla, California, USA.
Dina RaafatInstitute of Immunology, University Medicine Greifswald, Greifswald, Germany.
Kevin FechtnerInstitute of Immunology, University Medicine Greifswald, Greifswald, Germany.
Luise HerzogInstitute of Immunology, University Medicine Greifswald, Greifswald, Germany.
Thomas P KohlerDepartment of Molecular Genetics and Infection Biology, Interfaculty Institute for Genetics and Functional Genomics, Center for Functional Genomics of Microbes, University of Greifswald, Greifswald, Germany.
Rabea SchlüterImaging Center of the Department of Biology, University of Greifswald, Greifswald, Germany.
Alexander RederDepartment of Functional Genomics, Interfaculty Institute for Genetics and Functional Genomics, Center for Functional Genomics of Microbes, University of Greifswald, Greifswald, Germany.
Silva HoltfreterInstitute of Immunology, University Medicine Greifswald, Greifswald, Germany.
George Y LiuDepartment of Pediatrics, Division of Infectious Diseases, University of California San Diego, La Jolla, California, USA.
Sven HammerschmidtDepartment of Molecular Genetics and Infection Biology, Interfaculty Institute for Genetics and Functional Genomics, Center for Functional Genomics of Microbes, University of Greifswald, Greifswald, Germany.
Uwe VölkerDepartment of Functional Genomics, Interfaculty Institute for Genetics and Functional Genomics, Center for Functional Genomics of Microbes, University of Greifswald, Greifswald, Germany.
Victor J TorresDepartment of Microbiology, New York University Grossman School of Medicine, New York, USA.ORCID 0000-0002-7126-0489
Jan Maarten van DijlDepartment of Medical Microbiology, University of Groningen, University Medical Center, Groningen, the Netherlands.ORCID 0000-0002-5688-8438
Christopher H LilligInstitute for Medical Biochemistry and Molecular Biology, University Medicine Greifswald, Greifswald, Germany.
Barbara M Bröker *Institute of Immunology, University Medicine Greifswald, Greifswald, Germany.ORCID 0000-0002-5020-8542
Murty N Darisipudi *Institute of Immunology, University Medicine Greifswald, Greifswald, Germany.ORCID 0000-0002-3315-4570
Universitätsmedizin Greifswald · DEUniversität Greifswald · DENew York University · USUniversity Medical Center Groningen · NLUniversity of California San Diego · US

Funding

Mechanistic Studies Of The Staphylococcus aureus LukAB CytotoxinR01AI099394 · NIAID · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI Victor J. Torres · 2013 to 2026
$6.1M
Redefining the role of autophagy in bacterial diseaseR01AI121244 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI Ken Hashigiwa Cadwell · 2017 to 2026
$5.6M
Contribution of LukED to Staphylococcus aureus pathobiologyR01AI105129 · NIAID · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI TORRES, VICTOR J. · 2014 to 2023
$4.9M
Mechanisms of MRSA intestinal colonizationR01AI140754 · NIAID · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI SHOPSIN, BO · 2020 to 2024
$3.5M
Host-pathogen interactions during hospital adaptation of MRSAR01AI137336 · NIAID · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI SHOPSIN, BO, YANAI, ITAI · 2019 to 2022
$3.3M
Alternatively activated macrophages during helminth infectionR01AI133977 · NIAID · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI TORRES, VICTOR J. · 2017 to 2021
$2.4M
NIAID NIH HHS R01 AI099394NIAID NIH HHS R01 AI105129NIAID NIH HHS R01 AI121244NIAID NIH HHS R01 AI133977NIAID NIH HHS R01 AI137336NIAID NIH HHS R01 AI140754
6 · The paper itself

Abstract

importanceThe prevalence of multidrug-resistant

Indexed as

Bacterial ProteinsCation Transport ProteinsCytokinesMethicillin-Resistant Staphylococcus aureusNLR Family, Pyrin Domain-Containing 3 ProteinStaphylococcal InfectionsToll-Like Receptor 4Caspase 1HumansInflammasomesIronBacterial ProteinsCaspase 1Cation Transport ProteinsCytokinesInflammasomesIronIsdB protein, Staphylococcus aureusNLR Family, Pyrin Domain-Containing 3 ProteinTLR4 protein, humanToll-Like Receptor 4cytokinesinnate immunityIsdBNLRP3 inflammasomeStaphylococcus aureusTLR4

Identifiers

PMID38112465
PMCPMC10790753
OpenAlexW4389948763

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.