Evidence map›Paper›PMID 38112459›Full record

ArticleJournal of applied biomedicine2023

Effect of Usnea longissima ethyl acetate extract on acute oxidative and inflammatory lung damage from Staphylococcus aureus infection in rats.

Bulent Dabanlioglu, Bahadir Suleyman, Renad Mammadov, Bulent Yavuzer, Sumeyye Akyuz, Onder Akkas, Behzad Mokhtare, Emine Akyuz Turumtay, Durdu Altuner, Taha Abdulkadir Coban and 1 more

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Article in Journal of applied biomedicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 67% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Bulent DabanliogluErzincan Binali Yildirim University, Faculty of Medicine, Department of Medical Microbiology, Erzincan, Turkey.
Bahadir SuleymanErzincan Binali Yildirim University, Faculty of Medicine, Department of Pharmacology, Erzincan, Turkey.
Renad MammadovErzincan Binali Yildirim University, Faculty of Medicine, Department of Pharmacology, Erzincan, Turkey.
Bulent YavuzerErzincan Binali Yildirim University, Faculty of Medicine, Department of Pharmacology, Erzincan, Turkey.
Sumeyye AkyuzErzincan Binali Yildirim University, Faculty of Medicine, Department of Medical Microbiology, Erzincan, Turkey.
Onder AkkasErzincan Binali Yildirim University, Faculty of Medicine, Department of Medical Microbiology, Erzincan, Turkey.
Behzad MokhtareAtaturk University, Faculty of Veterinary Medicine, Department of Pathology, Erzurum, Turkey.
Emine Akyuz TurumtayRecep Tayyip Erdogan University, Faculty of Science, Department of Chemistry, Rize, Turkey.
Durdu AltunerErzincan Binali Yildirim University, Faculty of Medicine, Department of Pharmacology, Erzincan, Turkey.
Taha Abdulkadir CobanErzincan Binali Yildirim University, Faculty of Medicine, Department of Medical Biochemistry, Erzincan, Turkey.
Halis SuleymanErzincan Binali Yildirim University, Faculty of Medicine, Department of Pharmacology, Erzincan, Turkey.
Erzincan University · TRAtatürk University · TRRecep Tayyip Erdoğan University · TR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The role of oxidants and proinflammatory cytokines in the pathogenesis of pneumonia caused by Staphylococcus aureus (S. aureus) has been demonstrated. The present study aims to investigate the protective effect of ethyl acetate extract (EtOAc) obtained from Usnea longissima (UL) against acute oxidative and inflammatory lung damage due to S. aureus infection in rats. Albino Wistar-type male rats were divided into three groups: Healthy (HG), S. aureus inoculated (SaG), and S. aureus inoculated + ULEtOAc administered (SUL). SaG (n = 6) and SUL (n = 6) group rats' left nostrils (excluding HG) were inoculated with 0.1 ml bacterial mixture. After 24 hours, ULEtOAc (50 mg/kg) was administered orally to the SUL group, and the same volume of normal saline was administered orally to the HG (n = 6) and SaG groups. This procedure was performed once a day for seven days. Levels of oxidant and antioxidant parameters such as malondialdehyde (MDA) and total glutathione (tGSH), as well as pro-inflammatory cytokine levels such as nuclear factor-kappa B (NF-κB), tumor necrosis factor-alpha (TNF-α), interleukin-one beta (IL-1β), were measured in removed lung tissues. Tissues were also examined histopathologically. Biochemical results showed that ULEtOAc significantly suppressed the increase of MDA, NF-κB, TNF-α, and IL-1β levels and the decrease of tGSH caused by S. aureus in lung tissue. S. aureus inoculation caused severe mononuclear cell infiltration in interstitial areas, severe lymphoid hyperplasia in bronchial-associated lymphoid tissue and severe alveolar edema, histopathologically. Treatment with ULEtOAc had an attenuating effect on these histopathological findings. Experimental results from this study suggest that ULEtOAc may be beneficial in treating S. aureus-induced oxidative and inflammatory lung damage.

Indexed as

PneumoniaStaphylococcal InfectionsAcetatesAnimalsCytokinesGlutathioneLungMaleNF-kappa BOxidative StressParmeliaceaeRatsRats, WistarStaphylococcus aureusTumor Necrosis Factor-alphaAcetatesCytokinesethyl acetateGlutathioneNF-kappa BTumor Necrosis Factor-alphaEthyl acetate extractLungOxidative and inflammatoryRatsStaphylococcus aureusUsnea longissima

Identifiers

PMID38112459
OpenAlexW4389441518

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.