Evidence map›Paper›PMID 38111912›Full record

ArticleTranslational medicine of aging2023

Age-related Changes of GAD1 mRNA Expression in the Central Inferior Colliculus.

Christina C Koehler, Laila S Almassri, Nick Tokar, Amir M Mafi, Mitchell J O'Hara, Jesse W Young, Jeffrey G Mellott

Open access · goldAbstract read
In one paragraph

Article in Translational medicine of aging, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.8field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Christina C KoehlerDepartment of Anatomy and Neurobiology Northeast Ohio Medical University Rootstown, OH USA.
Laila S AlmassriDepartment of Anatomy and Neurobiology Northeast Ohio Medical University Rootstown, OH USA.
Nick TokarDepartment of Anatomy and Neurobiology Northeast Ohio Medical University Rootstown, OH USA.
Amir M MafiThe Ohio State College of Medicine The Ohio State Columbus, OH USA.
Mitchell J O'HaraDepartment of Anatomy and Neurobiology Northeast Ohio Medical University Rootstown, OH USA.
Jesse W YoungDepartment of Anatomy and Neurobiology Northeast Ohio Medical University Rootstown, OH USA.
Jeffrey G MellottDepartment of Anatomy and Neurobiology Northeast Ohio Medical University Rootstown, OH USA.
Northeast Ohio Medical University · USColumbus State Community College · US

Funding

Age-related GABAergic loss in the central auditory circuitsR01DC017708 · NIDCD · NORTHEAST OHIO MEDICAL UNIVERSITY · PI MELLOTT, JEFFREY GARRETT · 2020 to 2024
$1.7M
NIDCD NIH HHS R01 DC017708
6 · The paper itself

Abstract

Encoding sounds with a high degree of temporal precision is an essential task for the inferior colliculus (IC) to perform and maintain the accurate processing of sounds and speech. However, the age-related reduction of GABAergic neurotransmission in the IC interrupts temporal precision and likely contributes to presbycusis. As presbycusis often manifests at high or low frequencies specifically, we sought to determine if the expression of mRNA for glutamic decarboxylase 1 (GAD1) is downregulated non-uniformly across the tonotopic axis or cell size range in the aging IC. Using single molecule

Indexed as

agingGABAGAD1 mRNAinferior colliculussmFISH

Identifiers

PMID38111912
PMCPMC10727507
OpenAlexW4366608878

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.