Evidence map›Paper›PMID 38111858›Full record

ArticleNature reviews. Methods primers2022

Modulating cell signalling in vivo with magnetic nanotransducers.

Gabriela Romero, Jimin Park, Florian Koehler, Arnd Pralle, Polina Anikeeva

Abstract read
In one paragraph

Article in Nature reviews. Methods primers, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Article
  2. Remote-controlled genetics: A new frontier in precision therapy.Clinical and translational medicine · 2025
    Article
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  4. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Gabriela RomeroDepartment of Biomedical Engineering and Chemical Engineering, University of Texas at San Antonio, San Antonio, TX, USA.
Jimin ParkDepartment of Materials Science and Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.
Florian KoehlerResearch Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, MA, USA.
Arnd PralleDepartment of Physics, University at Buffalo, the State University of New York, Buffalo, NY, USA.
Polina AnikeevaDepartment of Materials Science and Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.

Funding

Fusion of nanomagnetic and viral tools to interrogate brain-body circuitsDP1AT011991 · NCCIH · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI ANIKEEVA, POLINA O · 2021 to 2025
$5.3M
Wireless Magnetomechanical Neuromodulation of Targeted CircuitsR01NS115576 · NINDS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI ANIKEEVA, POLINA O · 2020 to 2020
$1.6M
NCCIH NIH HHS DP1 AT011991NINDS NIH HHS R01 NS115576
6 · The paper itself

Abstract

Weak magnetic fields offer nearly lossless transmission of signals within biological tissue. Magnetic nanomaterials are capable of transducing magnetic fields into a range of biologically relevant signals in vitro and in vivo. These nanotransducers have recently enabled magnetic control of cellular processes, from neuronal firing and gene expression to programmed apoptosis. Effective implementation of magnetically controlled cellular signalling relies on careful tailoring of magnetic nanotransducers and magnetic fields to the responses of the intended molecular targets. This primer discusses the versatility of magnetic modulation modalities and offers practical guidelines for selection of appropriate materials and field parameters, with a particular focus on applications in neuroscience. With recent developments in magnetic instrumentation and nanoparticle chemistries, including those that are commercially available, magnetic approaches promise to empower research aimed at connecting molecular and cellular signalling to physiology and behaviour in untethered moving subjects.

Identifiers

PMID38111858
PMCPMC10727510

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.