Evidence map›Paper›PMID 38111766›Full record

ArticleWorld journal of gastrointestinal surgery2023

Multi-national observational study to assess quality of life and treatment preferences in patients with Crohn's perianal fistulas.

Chitra Karki, Amod Athavale, Vijay Abilash, Gary Hantsbarger, Parnia Geransar, Kate Lee, Slobodan Milicevic, Marko Perovic, Leanne Raven, Magdalena Sajak-Szczerba and 3 more

Abstract read
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In one paragraph

Article in World journal of gastrointestinal surgery, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
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  4. Article
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  6. Sexual dysfunction is highly prevalent in patients with active perianal fistulizing Crohn's disease: Outcomes from a large national prospective cohort study.Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Chitra KarkiGlobal Evidence and Outcomes-Gastroenterology, Takeda Pharmaceuticals United States, Inc, Cambridge, MA 02139, United States. chitra.karki@takeda.com.
Amod AthavaleTrinity Partners, LLC, Waltham, MA 02451-7528, United States.
Vijay AbilashTrinity Partners, LLC, Waltham, MA 02451-7528, United States.
Gary HantsbargerObservational Research, Takeda Pharmaceuticals United States, Inc, Cambridge, MA 02139, United States.
Parnia GeransarMedical Affairs, Takeda Pharmaceuticals International Co., Opfikon 8152, Zurich, Switzerland.
Kate LeeResearch and Patient Programs, Crohn's and Colitis Canada, 600-60 St. Clair Avenue East, Toronto M4T 1N5, Ontario, Canada.
Slobodan MilicevicMedical Affairs, Takeda Pharmaceuticals International Co., Opfikon 8152, Zurich, Switzerland.
Marko PerovicTreasurer, European Federation of Crohn's & Ulcerative Colitis Associations, Brussels B 1000, Belgium.
Leanne RavenCrohn's and Colitis Australia, Camberwell South, VIC 3124, Australia.
Magdalena Sajak-SzczerbaEuropean Federation of Crohn's & Ulcerative Colitis Associations, Brussels B 1000, Belgium.
Abigail SilberTrinity Partners, LLC, Waltham, MA 02451-7528, United States.
Annabelle YoonJapan Medical Office, Takeda Pharmaceutical Company Limited, Tokyo 103-8668, Japan.
Phil TozerDepartment of Colorectal Surgery, St Mark's Hospital and Academic Institute, London HA1 3UJ, United Kingdom.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPatients with Crohn's disease (CD) are at risk of developing complications such as perianal fistulas. Patients with Crohn's perianal fistulas (CPF) are affected by fecal incontinence (FI), bleeding, pain, swelling, and purulent perianal discharge, and generally face a higher treatment burden than patients with CD without CPF.

aimTo gain insights into the burden of illness/quality of life in patients with CPF and their treatment preferences and satisfaction.

methodsThis cross-sectional observational study was conducted in patients with CD aged 21-90 years

resultsIn total, 929 patients were recruited (cohort 1,

conclusionThe burden of illness in CD is significantly higher for patients with CPF and patients rate lower postoperative discomfort and higher healing rates as the most desirable treatment attributes.

Indexed as

Burden of illnessCrohn’s diseaseDiscrete choice experimentPatient-reported outcomesPerianal fistulasTreatment preferences

Identifiers

PMID38111766
PMCPMC10725550

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.