ArticleAnimal models and experimental medicine2024
Simple procedure for assessing diffuse subarachnoid hemorrhage successfully created using filament perforation method in mice.
Article in Animal models and experimental medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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3 citing papers in PubMed, 5 citations in OpenAlex.
- Dual-energy X-ray absorptiometry for detecting neurogenic pulmonary edema in a mouse model of subarachnoid hemorrhage.Animal models and experimental medicine · 2025Article
- Optimization and evaluation of an experimental subarachnoid hemorrhage model in mice.Scientific reports · 2025Article
- Simple procedure for assessing diffuse subarachnoid hemorrhage successfully created using filament perforation method in mice.Animal models and experimental medicine · 2024Article
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6 authors at 3 institutions in 1 country.
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Abstract
The murine model of subarachnoid hemorrhage (SAH) is a valuable experimental tool for investigating molecular and cellular mechanisms, and the endovascular filament perforation technique can be used to simulate prominent pathophysiological features observed after human SAH; however, current validation methods for assessing an appropriate SAH model are limited. Here, we introduce a simple procedure for selecting a mouse model of diffuse SAH. SAH was induced in 24 mice using a standard filament perforation method. After confirming survival at 24 h, SAH was scored 0-1 based on T2*-weighted images on whole-brain magnetic resonance imaging (MRI) and visual surveillance of the cisterna magna (CM) through the dura mater. The CM-based SAH grading correlated well with a reference parameter defined by extracted brain (r
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