Evidence map›Paper›PMID 38111308›Full record

ArticleCancer medicine2024

Nutritional status associated with clinical outcomes in children with solid tumors: A retrospective cohort study from China.

Yongzhen Li, Zhongying Lu, Ao Ma, Wei Yao, Rui Dong, Kai Li, Min Wu, Kuiran Dong, Tian Qian

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 6 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Yongzhen LiClinical nutrition Department, Children's Hospital of Fudan University, Shanghai, China.ORCID 0000-0002-7139-3919
Zhongying LuClinical nutrition Department, Children's Hospital of Fudan University, Shanghai, China.
Ao MaPediatric Clinical Research Unit, Department of Research Management, Children's Hospital of Fudan University, Shanghai, China.
Wei YaoDepartment of Oncology, Children's Hospital of Fudan University, Shanghai, China.
Rui DongDepartment of Oncology, Children's Hospital of Fudan University, Shanghai, China.
Kai LiDepartment of Oncology, Children's Hospital of Fudan University, Shanghai, China.ORCID 0000-0001-5050-0175
Min WuDepartment of Oncology, Children's Hospital of Fudan University, Shanghai, China.
Kuiran DongDepartment of Oncology, Children's Hospital of Fudan University, Shanghai, China.
Tian QianClinical nutrition Department, Children's Hospital of Fudan University, Shanghai, China.
Children's Hospital of Fudan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo investigate the long-term changes in nutritional status in children with solid tumors during treatment and the relationship between nutritional status and clinical outcomes.

methodsThis study was a retrospective medical records review of data from children who were diagnosed with solid tumors and followed up for more than 3 months from January 2016 to December 2021 in China. Patient demographics and clinical information, including nutritional status, parenteral nutrition use, intensive care unit (ICU) transfers, infection during hospitalization, hospitalization frequency, length of stay, hospitalization costs and antibiotic costs, were collected to analyze the nutritional status of children with different types of solid tumors, the dynamic changes in nutritional status during treatment, and the relationship between nutritional status and clinical outcomes.

resultsAmong the 764 patients (383 males (50.1%); 381 females (49.9%); mean age: 2.58 years), 41.6% of the solid tumors were neuroblastomas, 17.1% were hepatoblastomas, and Wilms tumors as the third most common solid tumors (8.9%). The median follow-up duration was 6 months (range: 3-40 months). At diagnosis, the proportion of children who were undernourished (underweight and wasting) versus overweight or obese were 26.71% versus 5.21% (25.86% vs. 2.89% in the third month; 29.77% vs. 2.28% in the sixth month; 24.77% vs. 3.27% in the 12th month). The body mass index Z scores decreased from the initial values after the first month (-0.56 (-1.47, 0.23) vs. -0.44 (-1.29, 0.41)) but improved later and decreased again at 6 months. The children in the undernutrition group had longer hospital stays (p < 0.001), higher hospitalization costs (p < 0.001), higher antibiotic costs (p < 0.001), a higher risk of neutropenia (OR = 4.781 (95% CI: 1.571-14.553), p = 0.006), and a higher risk of ICU transfers (OR = 1.498 (95% CI: 1.010-2.224), p = 0.044). No significant differences in those associations by malnutrition and infection, ICU duration, or length of parenteral nutrition were observed.

conclusionThere is a considerable prevalence of malnutrition in children with solid tumors. Malnutrition is related to adverse clinical outcomes and increases in total hospital expenses and antibiotic costs.

Indexed as

NeoplasmsNutritional StatusAdolescentChildChild, PreschoolChinaFemaleHepatoblastomaHospitalizationHumansInfantLength of StayMaleMalnutritionNeuroblastomaRetrospective Studieschildrenclinical outcomesmalnutritionnutritional statussolid tumorsundernutrition

Identifiers

PMID38111308
PMCPMC10807599
OpenAlexW4389958333

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.