Evidence map›Paper›PMID 38111180›Full record

ArticleDevelopmental science2024

Context-dependent approach and avoidance behavioral profiles as predictors of psychopathology.

Caroline M Kelsey, Anna Fasman, Kelsey Quigley, Kelli Dickerson, Michelle Bosquet Enlow, Charles A Nelson

Open access · bronzeAbstract read
In one paragraph

Article in Developmental science, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. The association between temperament and polygenic score for psychopathology from infancy to middle childhood.Journal of child psychology and psychiatry, and allied disciplines · 2025
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Caroline M KelseyDepartment of Pediatrics, Division of Developmental Medicine, Boston Children's Hospital, Boston, Massachusetts, USA.ORCID 0000-0001-8384-023X
Anna FasmanDepartment of Pediatrics, Division of Developmental Medicine, Boston Children's Hospital, Boston, Massachusetts, USA.
Kelsey QuigleyDepartment of Pediatrics, Division of Developmental Medicine, Boston Children's Hospital, Boston, Massachusetts, USA.
Kelli DickersonDepartment of Pediatrics, Division of Developmental Medicine, Boston Children's Hospital, Boston, Massachusetts, USA.
Michelle Bosquet EnlowDepartment of Psychiatry and Behavioral Sciences, Boston Children's Hospital, Boston, Massachusetts, USA.
Charles A NelsonDepartment of Pediatrics, Division of Developmental Medicine, Boston Children's Hospital, Boston, Massachusetts, USA.
Boston Children's Hospital · US

Funding

The Development of Face ProcessingR01MH078829 · NIMH · BOSTON CHILDREN'S HOSPITAL · PI Michelle A Bosquet Enlow · 2006 to 2026
$14.8M
Genetic Analysis and Manipulation Core (GAEC)P50HD105351 · NICHD · BOSTON CHILDREN'S HOSPITAL · PI SCOTT Loren POMEROY, MUSTAFA SAHIN · 2021 to 2026
$9.4M
Attention-based neural response to threat moderates the expression of BIF32HD105312 · NICHD · BOSTON CHILDREN'S HOSPITAL · PI KELSEY, CAROLINE M. · 2021 to 2023
$198k
NICHD NIH HHS F32 HD105312NICHD NIH HHS P50 HD105351NIMH NIH HHS R01 MH078829
6 · The paper itself

Abstract

Inhibition (a temperamental profile characterized by elevated levels of avoidance behaviors) is associated with increased likelihood for developing anxiety and depression, whereas exuberance (a temperamental profile characterized by elevated levels of approach behaviors) is associated with increased likelihood for developing externalizing conditions (e.g., attention deficit/hyperactivity disorder and conduct disorder). However, not all children who exhibit high levels of approach or avoidance behaviors develop emotional or behavioral problems. In this preregistered study, we assessed context-dependent profiles of approach and avoidance behaviors in 3-year-old children (N = 366). Using latent profile analysis, four groups were identified: nonsocial approachers, social approachers, social avoiders, and nonsocial avoiders. Analyses revealed that there were minimal differences in internalizing and externalizing symptoms across the four context-dependent groups. However, exploratory analyses assessed whether high levels of approach or avoidance combined across contexts, similar to findings reported in prior work, were related to psychopathology. Children identified as high in avoidance behavior at 3 years of age were more likely to show internalizing symptoms at 3 years of age but not at 5 years of age. Children high in approach were more likely to meet criteria for anxiety and externalizing disorders by age 5 years. These findings further our understanding of individual differences in how young children adjust their behavior based on contextual cues and may inform methods for identifying children at increased likelihood for the development of emotional and behavioral problems. RESEARCH HIGHLIGHTS: Context-dependent approach and avoidance profiles were identified in 3-year-old children using a person-centered approach. Children who were high in approach behavior, regardless of context, at age three had a higher likelihood for developing an anxiety or externalizing disorder by age five. These findings may help identify children at increased risk of developing emotional and behavioral problems.

Indexed as

Attention Deficit Disorder with HyperactivityPsychopathologyAnxietyAnxiety DisordersChild, PreschoolDepressionHumansapproachbehavioral motivationbehavioral problemsperson‐centeredpsychopathology

Identifiers

PMID38111180
PMCPMC10997460
OpenAlexW4389952015

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.