Evidence map›Paper›PMID 38110921›Full record

ArticleBMC medicine2023

Impact of maternal age and body mass index on the structure and function of the heart in newborns: a Copenhagen Baby Heart Study.

Mette Marie Olsen Nørregaard, Saima Basit, Anne-Sophie Sillesen, Anna Axelsson Raja, Finn Stener Jørgensen, Kasper Karmark Iversen, Henning Bundgaard, Heather Allison Boyd, Ruth Ottilia Birgitta Vøgg

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in BMC medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02753348 (Copenhagen Baby Heart), which is not on this map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
4.1field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02753348 completednot on this map

Copenhagen Baby Heart

TypeobservationalSponsorHenning BundgaardRan2016 to 2018Enrolled25,000ConditionsCongenital Heart DiseaseArmsEchocardiography, Blood analysis from umbilical cord blood, ECG, Measurement of oxygen saturation
3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 7 citations in OpenAlex.

  1. Echocardiographic assessment of cardiac growth in children with structurally normal hearts.American heart journal plus : cardiology research and practice · 2026
    Article
  2. Article
  3. Cardiac morphology and flow dynamics in children born to hypertensive pregnancies.European heart journal. Imaging methods and practice · 2026
    Article
  4. Prediction of Cyanotic Congenital Heart Disease Risk in U.S. Births.Journal of cardiovascular development and disease · 2026
    Article
  5. Article
  6. Article
  7. Article
  8. [Mechanisms of the Effect of Maternal Age-Related Oocyte Aging on Fertility: Transcriptomic Sequencing Analysis of a Zebrafish Model].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2024
    Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Mette Marie Olsen NørregaardDepartment of Cardiology, Copenhagen University Hospital Herlev-Gentofte, Herlev, Denmark. Mette.Marie.Olsen.Noerregaard@regionh.dk.
Saima BasitDepartment of Epidemiology, Statens Serum Institut, Copenhagen, Denmark.
Anne-Sophie SillesenDepartment of Cardiology, Copenhagen University Hospital Herlev-Gentofte, Herlev, Denmark.
Anna Axelsson RajaDepartment of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.
Finn Stener JørgensenDepartment of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.
Kasper Karmark IversenDepartment of Cardiology, Copenhagen University Hospital Herlev-Gentofte, Herlev, Denmark.
Henning BundgaardDepartment of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.
Heather Allison BoydDepartment of Epidemiology, Statens Serum Institut, Copenhagen, Denmark.
Ruth Ottilia Birgitta VøggDepartment of Cardiology, Copenhagen University Hospital Herlev-Gentofte, Herlev, Denmark.
Gentofte Hospital · DKUniversity of Copenhagen · DKStatens Serum Institut · DKCopenhagen University Hospital · DK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMaternal obesity and advanced age have been associated with an increased risk of structural congenital heart defects in the offspring. Whether these factors may also cause abnormalities in infant cardiac dimension and function is unknown. This study investigates whether maternal body mass index (BMI) and maternal age are associated with changes in left ventricular (LV) dimensions and function in the newborn.

methodsInfants enrolled in the Copenhagen Baby Heart Study (CBHS), who were born at term, and contributed with a transthoracic echocardiography (TTE) within 60 days of birth were included. The exposure variables were prepregnancy maternal BMI (kg/m

resultsThe study cohort included 24,294 infants. Compared with infants in the BMI reference group, infants born to women with a BMI ≥ 25 kg/m

conclusionsSystematic population-based echocardiography of infants showed that a maternal prepregnancy BMI ≥ 25 kg/m CLINICAL

trial registrationApril 2016, Copenhagen Baby Heart, NCT02753348 .

Indexed as

EchocardiographyHeart VentriclesAdultBody Mass IndexDiastoleFemaleHumansInfant, NewbornMaleMaternal AgeBody mass indexEchocardiographyMaternal ageMaternal factorsNewborn heart

Identifiers

PMID38110921
PMCPMC10729451
OpenAlexW4389904008

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.