Evidence map›Paper›PMID 38110895›Full record

ArticleBMC genomics2023

Investigating the causal impact of gut microbiota on glioblastoma: a bidirectional Mendelian randomization study.

Chuan Zeng, Chaolong Zhang, Chunming He, Haimin Song

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Article in BMC genomics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  16. Gut Microbiota and Gastrointestinal Polyps: Unveiling the Causal Connection.The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2025
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  19. Causal Relationship Between Gut Microbiota and Gastrointestinal Polyps: A Mendelian Randomization Study.The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Chuan ZengThe First Clinical Medical College of Gannan Medical University, Ganzhou City, 341000, Jiangxi Province, China.
Chaolong ZhangThe First Clinical Medical College of Gannan Medical University, Ganzhou City, 341000, Jiangxi Province, China.
Chunming HeDepartment of Neurosurgery, First Affiliated Hospital of Gannan Medical University, Qingnian Road, Ganzhou City, 341000, Jiangxi Province, China. hechunming998@sina.com.
Haimin SongDepartment of Neurosurgery, First Affiliated Hospital of Gannan Medical University, Qingnian Road, Ganzhou City, 341000, Jiangxi Province, China. haimin1204@163.com.

Funding

development plan-First Affiliated Hospital of Gannan Medical College 2023LNS36663iangxi Provincial Natural Science Foundation 20232BAB206108Jiangxi Provincial Health Commission science and technology plan SKJP220236456the Research Initiation Project of First Affiliated Hospital of Gannan Medical University QD202316
6 · The paper itself

Abstract

backgroundCurrently, the influence of microbiota on the occurrence, progression, and treatment of cancer is a topic of considerable research interest. Therefore, based on the theory of the gut-brain axis proved by previous studies, our objective was to uncover the causal relationship between glioblastoma and the gut microbiome using Mendelian randomization analysis.

methodsWe conducted a bidirectional Mendelian randomization study using summary statistics of gut microbiota derived from the MiBioGen consortium, the largest database of gut microbiota. Summary statistics for glioblastoma were obtained from IEU OpenGWAS project, which included 91 cases and 218,701 controls. We assessed the presence of heterogeneity and horizontal pleiotropy in the analyzed data. We primarily employed the inverse variance weighting method to investigate the causal relationship between gut microbiota and glioblastoma after excluding cases of horizontal pleiotropy. Four other analysis methods were employed as supplementary. Excluding abnormal results based on leave-one-out sensitivity analysis. Finally, reverse Mendelian randomization analysis was performed.

resultsFour genus-level taxa and one family-level taxa exhibited causal associations with glioblastoma. And these results of reverse Mendelian randomization analysis shown glioblastoma exhibited causal associations with three genus-level taxa and one family-level taxa. However, the Prevotella7(Forward, P=0.006, OR=0.34, 95%CI:0.158-0.732; Reverse, P=0.004, OR=0.972, 95%CI:0.953-0.991) shown the causal associations with glioblastoma in the bidirectional Mendelian randomization.

conclusionsIn this bidirectional Mendelian randomization study, we identified five gut microbiota species with causal associations to glioblastoma. However, additional randomized controlled trials are required to clarify the impact of gut microbiota on glioblastoma and to reveal its precise mechanisms.

Indexed as

Gastrointestinal MicrobiomeGlioblastomaMicrobiotaDatabases, FactualGenome-Wide Association StudyHumansMendelian Randomization AnalysisCausalityGlioblastomaGut-brain axisGut microbiotaMendelian randomization

Identifiers

PMID38110895
PMCPMC10726622

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.