ArticleScientific reports2023
Hemodynamic effects of entry and exit tear size in aortic dissection evaluated with in vitro magnetic resonance imaging and fluid-structure interaction simulation.
Article in Scientific reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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19 citing papers in PubMed.
- Patient-Specific Fluid-Structure Interaction Simulations Suggest Wall-Shear-Stress-Related Biomarkers in Type B Dissection Associated with Marfan Syndrome.Annals of biomedical engineering · 2026Article
- Multimodal imaging of acquired aortic diseases: clinical efficacy, comparative analysis, and future perspectives.The international journal of cardiovascular imaging · 2026Review
- Deep learning-driven false-lumen volumes predict adverse remodeling better than diameter in patients with residual aortic dissection on CT.European radiology · 2026Article
- In silico modelling of aortic annuloplasty: hemodynamic assessment through in vitro experiments and in vivo MRI.Computer methods and programs in biomedicine · 2026Article
- Deep reinforcement learning for automatic anatomic CT landmark localization in Stanford Type B aortic dissection.Radiology advances · 2026Article
- Spectral Computed Tomography for the Detection and Characterization of Communications Between the True and the False Lumen in Aortic Dissections.Investigative radiology · 2026Article
- False Lumen Haemodynamics in Type B Aortic Dissection: An in Vitro Study Using PIV and Patient-Specific Flexible Phantoms.Annals of biomedical engineering · 2026Article
- Hemodynamic simulation in the aortic arch under anemic, diabetic, and healthy blood flow conditions using computational fluid dynamics.PloS one · 2026Article
- Investigating the role of structural wall stress in aortic growth prognosis in acute uncomplicated type B aortic dissection.Biomechanics and modeling in mechanobiology · 2025Article
- 3D-printed in vitro models of Stanford type B aortic dissection: A scoping review.Journal of vascular surgery cases and innovative techniques · 2025Article
- A Fluid-Structure Interaction Computational Study of Residual Aortic Dissection to Investigate the Influence of Mechanical Behaviour of Wall and Flap on Flows.International journal for numerical methods in biomedical engineering · 2025Article
- Simulation-Based Training in Aortic Aneurysm Surgery: Toward a New Educational Standard.Cureus · 2025Review
- Impact of Residual Intimal Flap Displacement Post-TEVAR on TBAD Haemodynamics in Compliant, Patient-specific CFD Simulations Informed by MRI.Annals of biomedical engineering · 2025Article
- Mechanisms of aortic dissection: From pathological changes to experimental andProgress in materials science · 2025Article
- Assessment of Aortic Dissection Remodeling With Patient-Specific Fluid-Structure Interaction Models.IEEE transactions on bio-medical engineering · 2025Article
- Can computational fluid dynamics simulations predict a distal stent graft-induced new entry after frozen elephant trunk operation?Frontiers in cardiovascular medicine · 2025Article
- 4D computed tomography assessment of ruptured triple-lumen type B aortic dissection: a case report.European heart journal. Case reports · 2024Article
- Investigating the role of thrombosis and false lumen orbital orientation in the hemodynamics of Type B aortic dissection.Scientific reports · 2024Article
- Multifactorial considerations in frozen elephant trunk selection and treatment strategies for acute type A aortic dissection.JTCVS open · 2024Article
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Abstract
Understanding the complex interplay between morphologic and hemodynamic features in aortic dissection is critical for risk stratification and for the development of individualized therapy. This work evaluates the effects of entry and exit tear size on the hemodynamics in type B aortic dissection by comparing fluid-structure interaction (FSI) simulations with in vitro 4D-flow magnetic resonance imaging (MRI). A baseline patient-specific 3D-printed model and two variants with modified tear size (smaller entry tear, smaller exit tear) were embedded into a flow- and pressure-controlled setup to perform MRI as well as 12-point catheter-based pressure measurements. The same models defined the wall and fluid domains for FSI simulations, for which boundary conditions were matched with measured data. Results showed exceptionally well matched complex flow patterns between 4D-flow MRI and FSI simulations. Compared to the baseline model, false lumen flow volume decreased with either a smaller entry tear (- 17.8 and - 18.5%, for FSI simulation and 4D-flow MRI, respectively) or smaller exit tear (- 16.0 and - 17.3%). True to false lumen pressure difference (initially 11.0 and 7.9 mmHg, for FSI simulation and catheter-based pressure measurements, respectively) increased with a smaller entry tear (28.9 and 14.6 mmHg), and became negative with a smaller exit tear (- 20.6 and - 13.2 mmHg). This work establishes quantitative and qualitative effects of entry or exit tear size on hemodynamics in aortic dissection, with particularly notable impact observed on FL pressurization. FSI simulations demonstrate acceptable qualitative and quantitative agreement with flow imaging, supporting its deployment in clinical studies.
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