ArticleNature human behaviour2024
Evidence from Finland and Sweden on the relationship between early-life diseases and lifetime childlessness in men and women.
Article in Nature human behaviour, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pregnancy in Women with Atopic Dermatitis: A Systematic Review of Concerns and Challenges.Acta dermato-venereologica · 2026Pooled it
- The association between musculoskeletal symptoms and work characteristics, demographic factors, depression, anxiety, insomnia, and shift work disorder: a cross-sectional study among Norwegian nurses.Industrial health · 2026Article
- Parenthood and mental health throughout the life course: A total population study.Social psychiatry and psychiatric epidemiology · 2026Article
- Genetic trade-offs in fertility and longevity explain the maintenance of disease-associated alleles in humans.Nature ecology & evolution · 2026Article
- Early Life BMI Trajectories and Associations With Childbirth and Infertility Among Women.JAMA network open · 2026Article
- Heterogenous long-term health and social outcomes of type 1 diabetes: a full population 30-year observational cohort study.American journal of epidemiology · 2026Observational
- Long-term socioeconomic outcomes in Danish children with moderate-to-severe atopic dermatitis.Journal of the European Academy of Dermatology and Venereology : JEADV · 2026Article
- Assortative Mating Across the Full Spectrum of Mental Disorders: A Nationwide Finnish Register Study.Biological psychiatry global open science · 2026Article
- Association between the number of children and depression in the population aged 50 years and older: a multi-national cross-sectional analysis.BMC psychiatry · 2025Article
- Reproductive and cognitive phenotypes in carriers of recessive pathogenic variants.Nature human behaviour · 2025Article
- Mental Disorders and Having a First Child Among Young Adults: A Nationwide Register-Based Cohort Study.BJOG : an international journal of obstetrics and gynaecology · 2025Article
- Effects of parental autoimmune diseases on type 1 diabetes in offspring can be partially explained by HLA and non-HLA polymorphisms.Cell genomics · 2025Article
- Socio-economic status is a social construct with heritable components and genetic consequences.Nature human behaviour · 2025Review
- Self-assessed Physical and Mental Health and Fertility Expectations of Men and Women Across the Life Course.Demography · 2025Article
- Number of children and dementia risk: a causal mediation analysis using data from the HUNT study linked with national registries in Norway.BMC neurology · 2025Article
- The interplay between male fertility, mental health and sexual function.Nature reviews. Urology · 2025Article
- Genetics of female and male reproductive traits and their relationship with health, longevity and consequences for offspring.Nature aging · 2024Review
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Authors and funding
13 authors.
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Abstract
The percentage of people without children over their lifetime is approximately 25% in men and 20% in women. Individual diseases have been linked to childlessness, mostly in women, yet we lack a comprehensive picture of the effect of early-life diseases on lifetime childlessness. We examined all individuals born in 1956-1968 (men) and 1956-1973 (women) in Finland (n = 1,035,928) and Sweden (n = 1,509,092) to the completion of their reproductive lifespan in 2018. Leveraging nationwide registers, we associated sociodemographic and reproductive information with 414 diseases across 16 categories, using a population and matched-pair case-control design of siblings discordant for childlessness (71,524 full sisters and 77,622 full brothers). The strongest associations were mental-behavioural disorders (particularly among men), congenital anomalies and endocrine-nutritional-metabolic disorders (strongest among women). We identified new associations for inflammatory and autoimmune diseases. Associations were dependent on age at onset and mediated by singlehood and education. This evidence can be used to understand how disease contributes to involuntary childlessness.
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