Evidence map›Paper›PMID 38110486›Full record

ArticleNPJ digital medicine2023

Augmented reality versus standard tests to assess cognition and function in early Alzheimer's disease.

Marijn Muurling, Casper de Boer, Srinivasan Vairavan, Robbert L Harms, Antonella Santuccione Chadha, Ioannis Tarnanas, Estefania Vilarino Luis, Dorota Religa, Martha Therese Gjestsen, Samantha Galluzzi and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NPJ digital medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Digital Psychiatry with Virtual Reality and Augmented Reality: Recent Advances and Limitations.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2026
    Review
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  10. The Digitized Memory Clinic.Nature reviews. Neurology · 2024
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Marijn MuurlingAlzheimer Center Amsterdam, Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc, Amsterdam, The Netherlands. m.muurling@amsterdamumc.nl.ORCID http://orcid.org/0000-0001-9397-4602
Casper de BoerAlzheimer Center Amsterdam, Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc, Amsterdam, The Netherlands.
Srinivasan VairavanJanssen Research & Development, LLC, 1125 Trenton Harbourton Road, Titusville, NJ, 08560, USA.ORCID http://orcid.org/0000-0001-7975-8436
Robbert L HarmsAltoida Inc., Washington, DC, USA.
Antonella Santuccione ChadhaAltoida Inc., Washington, DC, USA.
Ioannis TarnanasAltoida Inc., Washington, DC, USA.ORCID http://orcid.org/0000-0003-4069-6551
Estefania Vilarino LuisCentre de la mémoire, Université de Genève (UNIGE), Hôpitaux Universitaires de Genève, Geneva, Switzerland.
Dorota ReligaCenter for Alzheimer Research, Department of Neurobiology, Care Sciences and Society (NVS), Karolinska Institutet, Stockholm, Sweden.
Martha Therese GjestsenCentre for Age-related Medicine, Stavanger University Hospital, Stavanger, Norway.
Samantha GalluzziLaboratory Alzheimer's Neuroimaging & Epidemiology, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy.
Marta Ibarria SalaAce Alzheimer Center Barcelona - Universitat Internacional de Catalunya, Barcelona, Spain.
Ivan KoychevDepartment of Psychiatry, University of Oxford, Oxford, UK.
Lucrezia HausnerCentral Institute for Mental Health, Faculty Mannheim, University of Heidelberg, Heidelberg, Germany.
Mara GkiokaAlzheimer Hellas and Laboratory of Neurodegenerative Diseases, Center for Interdisciplinary Research and Innovation (CIRI - AUTh), Balkan Center, Aristotle University of Thessaloniki, Thessaloniki, Greece.
Dag AarslandCentre for Age-related Medicine, Stavanger University Hospital, Stavanger, Norway.
Pieter Jelle VisserAlzheimer Center Amsterdam, Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc, Amsterdam, The Netherlands.
Anna-Katharine BremInstitute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.ORCID http://orcid.org/0000-0003-0295-6834

Funding

Innovative Medicines Initiative (IMI) 806999
6 · The paper itself

Abstract

Augmented reality (AR) apps, in which the virtual and real world are combined, can recreate instrumental activities of daily living (IADL) and are therefore promising to measure cognition needed for IADL in early Alzheimer's disease (AD) both in the clinic and in the home settings. The primary aim of this study was to distinguish and classify healthy controls (HC) from participants with AD pathology in an early AD stage using an AR app. The secondary aims were to test the association of the app with clinical cognitive and functional tests and investigate the feasibility of at-home testing using AR. We furthermore investigated the test-retest reliability and potential learning effects of the task. The digital score from the AR app could significantly distinguish HC from preclinical AD (preAD) and prodromal AD (proAD), and preAD from proAD, both with in-clinic and at-home tests. For the classification of the proAD group, the digital score (AUC

Identifiers

PMID38110486
PMCPMC10728213

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.