Evidence map›Paper›PMID 38110035›Full record

ArticleThe Journal of biological chemistry2024

Peptide toxins that target vertebrate voltage-gated sodium channels underly the painful stings of harvester ants.

Samuel D Robinson, Jennifer R Deuis, Pancong Niu, Axel Touchard, Alexander Mueller, Vanessa Schendel, Nina Brinkwirth, Glenn F King, Irina Vetter, Justin O Schmidt

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of biological chemistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.9field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 5 countries.

Samuel D RobinsonInstitute for Molecular Bioscience, The University of Queensland, Queensland, Australia. Electronic address: sam.robinson@uq.edu.au.
Jennifer R DeuisInstitute for Molecular Bioscience, The University of Queensland, Queensland, Australia.
Pancong NiuInstitute for Molecular Bioscience, The University of Queensland, Queensland, Australia.
Axel TouchardCNRS, UMR Ecologie des forêts de Guyane - EcoFoG (AgroParisTech, CIRAD, INRAE, Université de Guyane, Université des Antilles), Kourou, France.
Alexander MuellerInstitute for Molecular Bioscience, The University of Queensland, Queensland, Australia; Centro de Investigación Biomédica CENBIO, Universidad UTE, Quito, Ecuador.
Vanessa SchendelInstitute for Molecular Bioscience, The University of Queensland, Queensland, Australia.
Nina BrinkwirthNanion Technologies, Munich, Germany.
Glenn F KingInstitute for Molecular Bioscience, The University of Queensland, Queensland, Australia; Australian Research Council Centre of Excellence for Innovations in Peptide and Protein Science, The University of Queensland, Brisbane, Queensland, Australia.
Irina VetterInstitute for Molecular Bioscience, The University of Queensland, Queensland, Australia; School of Pharmacy, The University of Queensland, Brisbane, Queensland, Australia.
Justin O SchmidtSouthwestern Biological Institute, Tucson, Arizona, USA.
The University of Queensland · AUAustralian Research Council · AUCentre National de la Recherche Scientifique · FRNanion (Germany) · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Harvester ants (genus Pogonomyrmex) are renowned for their stings which cause intense, long-lasting pain, and other neurotoxic symptoms in vertebrates. Here, we show that harvester ant venoms are relatively simple and composed largely of peptide toxins. One class of peptides is primarily responsible for the long-lasting local pain of envenomation via activation of peripheral sensory neurons. These hydrophobic, cysteine-free peptides potently modulate mammalian voltage-gated sodium (Na

Indexed as

AntsBites and StingsPainPeptidesToxins, BiologicalVoltage-Gated Sodium Channel BlockersVoltage-Gated Sodium ChannelsAnimalsSensory Receptor CellsVertebratesPeptidesToxins, BiologicalVoltage-Gated Sodium Channel BlockersVoltage-Gated Sodium Channelsion channelneuronpainPogonomyrmexvenom

Identifiers

PMID38110035
PMCPMC10821600
OpenAlexW4389849195

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.