ArticleNature2024
Functional and evolutionary significance of unknown genes from uncultivated taxa.
Open access · hybridAbstract read
In one paragraph
Article in Nature, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
67citing papers in PubMed, 1 pooled it
16.2field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
67 citing papers in PubMed, 1 synthesis or guideline pooled it, 98 citations in OpenAlex.
- The Utility of Lipidomic Analysis in Colorectal Cancer Diagnosis and Prognosis-A Systematic Review of Recent Literature.International journal of molecular sciences · 2024Pooled it
- Fecal microbiota transplantation alters the proteomic landscape of inflammation in HIV: identifying bacterial drivers.Microbiome · 2024Trial
- "Quadrupling" the protein family space with global metagenomics.Nucleic acids research · 2026Article
- Obligate cross-feeding of metabolites is common in soil microbial communities.Nature microbiology · 2026Article
- Molecular bioindicators for assessing environmental impacts of emerging contaminants.Fundamental research · 2026Review
- The microbial unknome, a repertoire for microbial chatting?Heredity · 2026Review
- Phylogenize2: robust phylogenetic methods link genes to phenotypes across host-associated and environmental microbiomes.bioRxiv : the preprint server for biology · 2026Article
- A robust, sensitive phylogenetic method enables gene-level metagenomic analyses.bioRxiv : the preprint server for biology · 2026Article
- Predicting functions of uncharacterized gene products from microbial communities.Nature biotechnology · 2026Article
- microntology: a lightweight, data-driven controlled vocabulary to describe earth's microbial habitats.Bioinformatics (Oxford, England) · 2026Article
- Honey bee nutritranscriptomics reveals key insights towards precision nutrition.Journal of advanced research · 2026Article
- Long-Read Sequencing for Species-Level Resolution of the Equine Gut Microbiota Reveals the Need for Improved Databases.Animals : an open access journal from MDPI · 2026Article
- Clustering the protein universe of life using DIAMOND DeepClust.Nature methods · 2026Article
- Evolutionary profile enhancement improves protein function annotation for remote homologs.bioRxiv : the preprint server for biology · 2026Article
- Discovering PETases: An Interlink Between Engineering Enzymes and Microbiomes.Environmental microbiology · 2026Review
- Article
- Navigating the conjugated metabolome.bioRxiv : the preprint server for biology · 2026Article
- Branched-chain amino acid specialization drove diversification within Calditenuaceae (Caldarchaeia) and enables their cultivation.Nature communications · 2026Article
- Efficient mucin O-glycan degradation by specific mucin degrading intestinal bacteria: towards understanding enzyme-glycan interactions.Glycobiology · 2026Article
- Retroelement expansions underlie genome evolution in stingless bees.BMC genomics · 2026Article
7 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
17 authors at 6 institutions in 5 countries.
Álvaro Rodríguez Del RíoCentro de Biotecnología y Genómica de Plantas, Universidad Politécnica de Madrid (UPM) - Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA-CSIC), Madrid, Spain.
Joaquín Giner-LamiaCentro de Biotecnología y Genómica de Plantas, Universidad Politécnica de Madrid (UPM) - Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA-CSIC), Madrid, Spain.ORCID 0000-0003-1553-8295
Carlos P CantalapiedraCentro de Biotecnología y Genómica de Plantas, Universidad Politécnica de Madrid (UPM) - Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA-CSIC), Madrid, Spain.ORCID 0000-0001-5263-533X
Jorge BotasCentro de Biotecnología y Genómica de Plantas, Universidad Politécnica de Madrid (UPM) - Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA-CSIC), Madrid, Spain.
Ziqi DengCentro de Biotecnología y Genómica de Plantas, Universidad Politécnica de Madrid (UPM) - Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA-CSIC), Madrid, Spain.
Ana Hernández-PlazaCentro de Biotecnología y Genómica de Plantas, Universidad Politécnica de Madrid (UPM) - Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA-CSIC), Madrid, Spain.ORCID 0000-0002-9844-7999
Martí Munar-PalmerCentro de Biotecnología y Genómica de Plantas, Universidad Politécnica de Madrid (UPM) - Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA-CSIC), Madrid, Spain.
Saray Santamaría-HernandoCentro de Biotecnología y Genómica de Plantas, Universidad Politécnica de Madrid (UPM) - Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA-CSIC), Madrid, Spain.
José J Rodríguez-HervaCentro de Biotecnología y Genómica de Plantas, Universidad Politécnica de Madrid (UPM) - Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA-CSIC), Madrid, Spain.
Hans-Joachim RuscheweyhDepartment of Biology, Institute of Microbiology and Swiss Institute of Bioinformatics, ETH Zürich, Zürich, Switzerland.ORCID 0000-0001-7473-6086
Lucas PaoliDepartment of Biology, Institute of Microbiology and Swiss Institute of Bioinformatics, ETH Zürich, Zürich, Switzerland.ORCID 0000-0003-0771-8309
Thomas S B SchmidtStructural and Computational Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany.ORCID 0000-0001-8587-4177
Shinichi SunagawaDepartment of Biology, Institute of Microbiology and Swiss Institute of Bioinformatics, ETH Zürich, Zürich, Switzerland.ORCID 0000-0003-3065-0314
Peer BorkStructural and Computational Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany.
Emilia López-SolanillaCentro de Biotecnología y Genómica de Plantas, Universidad Politécnica de Madrid (UPM) - Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA-CSIC), Madrid, Spain.ORCID 0000-0002-8578-7433
Luis Pedro CoelhoInstitute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai, China.
Jaime Huerta-CepasCentro de Biotecnología y Genómica de Plantas, Universidad Politécnica de Madrid (UPM) - Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA-CSIC), Madrid, Spain. j.huerta@csic.es.ORCID 0000-0003-4195-5025
Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria · ESSIB Swiss Institute of Bioinformatics · CHEuropean Molecular Biology Laboratory · DEInstituto de Bioquímica Vegetal y Fotosíntesis · ESMax Delbrück Center · DETranslational Research Institute · AU
Funding
National Programme for Fostering Excellence in Scientific and Technical Research
Abstract
Many of the Earth's microbes remain uncultured and understudied, limiting our understanding of the functional and evolutionary aspects of their genetic material, which remain largely overlooked in most metagenomic studies
Indexed as
ArchaeaBacteriaEcosystemEvolution, MolecularGenes, ArchaealGenes, BacterialGenomicsKnowledgeAntimicrobial PeptidesBiomarkersCell MovementColorectal NeoplasmsMetagenomicsMultigene FamilyPhylogenyReproducibility of ResultsAntimicrobial PeptidesBiomarkers
Identifiers
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Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.