ArticleNature2024
De novo design of high-affinity binders of bioactive helical peptides.
Abstract read
In one paragraph
Article in Nature, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 134 papers.
0numbers the graph read from it
0cells of the map it votes in
134citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
134 citing papers in PubMed.
- Engineering short-sequence elements for condensate-like assemblies by de novo design.Synthetic and systems biotechnology · 2027Article
- Global analysis of thermal and chemical denaturation using CheMelt: Thermodynamic dissection of highly thermostable de novo designed proteins.Protein science : a publication of the Protein Society · 2026Article
- Scalable Production of aPharmaceutics · 2026Article
- Beyond the structure-function paradigm: A comprehensive review of intrinsically disordered proteins.Biochemistry and biophysics reports · 2026Review
- Intracellular protein binders for imaging, control and future therapeutics.Nature biomedical engineering · 2026Review
- Applications of synthetic biology in biomedicine.Molecular biomedicine · 2026Review
- Diffusion-Based Protein Structure Design: Geometric Modelling, Validation Strategies, and Thermodynamic Challenges.International journal of molecular sciences · 2026Review
- Article
- Article
- Artificial intelligence in biologic drug discovery: A review of methodological evolution and therapeutic applications.Acta pharmaceutica Sinica. B · 2026Review
- Generative AI-drivenAntibody therapeutics · 2026Article
- A side-by-side biophysical comparison of five single-domain antibody scaffolds used for synthetic display libraries.The Journal of biological chemistry · 2026Article
- Bridging Generative AI and Diffusion Models With Molecular Simulation to Design Anti-Quorum-Sensing De novo Peptides Targeting LasR of Pseudomonas aeruginosa.Probiotics and antimicrobial proteins · 2026Article
- Benchmarking and behavioral characterization of LLM agents for protein design.bioRxiv : the preprint server for biology · 2026Article
- Targeting the Undruggable: Deep Learning-Driven Design of Peptide Therapeutics in Cancer.Pharmaceuticals (Basel, Switzerland) · 2026Review
- Modular Input-Output Biosensor Design UsingACS sensors · 2026Article
- Structure-Guided Design of Proteomimetics Targeting the SARS-CoV-2 S-RBD/hACE2 Interface.Journal of medicinal chemistry · 2026Article
- Tools For Building Artificial Biological Nanostructures.ACS nano · 2026Review
- Gene-in-gene coding generates dual-isoform Fha condensates to control type VI secretion system assembly.Nature communications · 2026Article
- Article
74 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
30 authors.
Susana Vázquez Torres *Department of Biochemistry, University of Washington, Seattle, WA, USA.
Philip J Y Leung *Department of Biochemistry, University of Washington, Seattle, WA, USA.
Preetham Venkatesh *Department of Biochemistry, University of Washington, Seattle, WA, USA.
Isaac D LutzDepartment of Biochemistry, University of Washington, Seattle, WA, USA.
Fabian HinkDepartment of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0003-3483-2596
Huu-Hien HuynhDepartment of Laboratory Medicine and Pathology, University of Washington, Seattle, WA, USA.
Jessica BeckerDepartment of Laboratory Medicine and Pathology, University of Washington, Seattle, WA, USA.
Andy Hsien-Wei YehDepartment of Biochemistry, University of Washington, Seattle, WA, USA.
David JuergensDepartment of Biochemistry, University of Washington, Seattle, WA, USA.ORCID 0000-0001-6425-8391
Nathaniel R BennettDepartment of Biochemistry, University of Washington, Seattle, WA, USA.ORCID 0000-0001-8590-1454
Andrew N HoofnagleDepartment of Laboratory Medicine and Pathology, University of Washington, Seattle, WA, USA.ORCID 0000-0002-6449-0243
Eric HuangDepartment of Genome Sciences, University of Washington, Seattle, WA, USA.
Michael J MacCossDepartment of Genome Sciences, University of Washington, Seattle, WA, USA.ORCID 0000-0003-1853-0256
Marc ExpòsitDepartment of Biochemistry, University of Washington, Seattle, WA, USA.
Gyu Rie LeeDepartment of Biochemistry, University of Washington, Seattle, WA, USA.ORCID 0000-0002-9119-5303
Asim K BeraDepartment of Biochemistry, University of Washington, Seattle, WA, USA.ORCID 0000-0001-9473-2912
Alex KangDepartment of Biochemistry, University of Washington, Seattle, WA, USA.
Joshmyn De La CruzDepartment of Biochemistry, University of Washington, Seattle, WA, USA.
Paul M LevineDepartment of Biochemistry, University of Washington, Seattle, WA, USA.
Xinting LiDepartment of Biochemistry, University of Washington, Seattle, WA, USA.
Mila LambDepartment of Biochemistry, University of Washington, Seattle, WA, USA.
Stacey R GerbenDepartment of Biochemistry, University of Washington, Seattle, WA, USA.
Analisa MurrayDepartment of Biochemistry, University of Washington, Seattle, WA, USA.
Piper HeineDepartment of Biochemistry, University of Washington, Seattle, WA, USA.
Elif Nihal KorkmazDepartment of Biochemistry, University of Washington, Seattle, WA, USA.
Jeff NivalaSchool of Computer Science and Engineering, University of Washington, Seattle, WA, USA.ORCID 0000-0002-8210-5417
Lance StewartDepartment of Biochemistry, University of Washington, Seattle, WA, USA.
Joseph L WatsonDepartment of Biochemistry, University of Washington, Seattle, WA, USA. jwatson3@uw.edu.
Joseph M RogersDepartment of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmark. joseph.rogers@sund.ku.dk.
David BakerDepartment of Biochemistry, University of Washington, Seattle, WA, USA. dabaker@uw.edu.ORCID 0000-0001-7896-6217
Funding
User Training and OutreachP30GM124165 · NIGMS · CORNELL UNIVERSITY · PI Nozomi Ando, J Christopher Fromme · 2018 to 2026
$34.2MProject 4: Novel reagent development to enable molecular characterizationU19AG065156 · NIA · UNIVERSITY OF WASHINGTON · PI MONTINE, THOMAS J · 2020 to 2024
$15.9MQuantifying proteins in plasma do democratize personalized medicine for patients with type 1 diabetesU01DK137097 · NIDDK · UNIVERSITY OF WASHINGTON · PI ANDREW N HOOFNAGLE, Michael MacCoss · 2023 to 2026
$3.4MQuantifying proteins in plasma to democratize personalized medicine for patients with type 1 diabetesU01DK121289 · NIDDK · UNIVERSITY OF WASHINGTON · PI HOOFNAGLE, ANDREW N · 2019 to 2021
$1.9MDe novo design of a generalizable protein biosensor platform for point-of-care testingR00EB031913 · NIBIB · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI YEH, HSIEN WEI · 2023 to 2025
$747kDe novo design of a generalizable protein biosensor platform for point-of-care testingK99EB031913 · NIBIB · UNIVERSITY OF WASHINGTON · PI YEH, HSIEN WEI · 2022 to 2022
$80kNIA NIH HHS U19 AG065156NIBIB NIH HHS K99 EB031913NIBIB NIH HHS R00 EB031913NIDDK NIH HHS U01 DK121289NIDDK NIH HHS U01 DK137097NIGMS NIH HHS P30 GM124165
Abstract
Many peptide hormones form an α-helix on binding their receptors
Indexed as
Computer-Aided DesignDeep LearningPeptidesProteinsBiosensing TechniquesDiffusionGlucagonLuminescent MeasurementsMass SpectrometryModels, MolecularParathyroid HormoneProtein Structure, SecondarySubstrate SpecificityGlucagonParathyroid HormonePeptidesProteins
Identifiers
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Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.