Evidence map›Paper›PMID 38109885›Full record

ReviewNutrition reviews2024

Impact of ketogenic diet on cardiovascular disease.

Mohamed S Zaghloul, Santiago Elizondo-Benedetto, Mohamed A Zayed

Registry-linked trialAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Nutrition reviews, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07495267 (Nutritional Ketosis as a Novel Therapeutic Strategy to Stabilize Chronic Aortic Dissection in Marfan Syndrome), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07495267 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

Nutritional Ketosis as a Novel Therapeutic Strategy to Stabilize Chronic Aortic Dissection in Marfan Syndrome

TypeinterventionalSponsorWashington University School of MedicineRan2026 to 2028Enrolled15ConditionsMarfan Syndrome, Aortic DissectionArmsKetogenic diet
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Mohamed S ZaghloulDepartment of Surgery, Section of Vascular Surgery, Washington University School of Medicine, St. Louis, MO, USA.
Santiago Elizondo-BenedettoDepartment of Surgery, Section of Vascular Surgery, Washington University School of Medicine, St. Louis, MO, USA.
Mohamed A ZayedDepartment of Surgery, Section of Vascular Surgery, Washington University School of Medicine, St. Louis, MO, USA.ORCID 0000-0001-6443-4527

Funding

PET Detection of CCR2 in Human AtherosclerosisR01HL150891 · NHLBI · WASHINGTON UNIVERSITY · PI GROPLER, ROBERT J., WOODARD, PAMELA K · 2020 to 2024
$3.7M
CCR2 Targeted Molecular Imaging and Treatment of Abdominal Aortic AneurysmsR01HL153436 · NHLBI · WASHINGTON UNIVERSITY · PI GROPLER, ROBERT J., ZAYED, MOHAMED A. · 2020 to 2023
$3.0M
Regulation of Endothelial Lipid Metabolism in the Setting of Diabetes and Critical Limb Ischemia to Prevent Surgical ComplicationsR01HL153262 · NHLBI · WASHINGTON UNIVERSITY · PI ZAYED, MOHAMED A. · 2021 to 2024
$2.1M
National Heart Lung and Blood Institute R01HL153436National Institute of HealthNHLBI NIH HHS R01 HL150891NHLBI NIH HHS R01 HL153262NHLBI NIH HHS R01 HL153436
6 · The paper itself

Abstract

objectivesA comprehensive review of the current literature was conducted to summarize the potential therapeutic and management roles of ketogenic diet (KD) for cardiovascular disease (CVD).

backgroundConsensus has not been reached on the optimal diet for individuals with cardiovascular risk factors. KDs are characterized by high-fat, low-carbohydrate, and appropriate protein content, and have gained popularity in recent years in the management of various conditions, including cardiovascular and metabolic diseases.

methodsOriginal research, systematic reviews, and meta-analyses available in the PubMed, Web of Science, and Google Scholar databases were reviewed.

resultsThe current body of preclinical and clinical evidence on the efficacy of KD in the management of CVD remains limited. Specific applications of KD seem to suggest a positive impact on management of CVD. However, conflicting results and a lack of precise molecular and biochemical mechanisms of action provide ample opportunity for future investigation.

conclusionMore multidisciplinary studies are needed to determine the true clinical benefit of KD in the management of CVD and so justify its expanded clinical use.

Indexed as

Cardiovascular DiseasesDiet, KetogenicHumansatherosclerosiscardiovascular diseasesketogenic dietlife stylenutrition

Identifiers

PMID38109885
PMCPMC12104557

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.