ArticleJournal of agricultural and food chemistry2024
Engineering a Plant Polyketide Synthase for the Biosynthesis of Methylated Flavonoids.
Article in Journal of agricultural and food chemistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 21 citations in OpenAlex.
- Engineering ofACS omega · 2026Article
- De novo biosynthesis of alpinetin enhanced by directed evolution of 5-O-methyltransferase.Microbial cell factories · 2026Article
- Integrative structural and physicochemical characterization of chalcone synthase enzymes from medicinal plants using AlphaFold, molecular docking, and molecular dynamics.Scientific reports · 2026Article
- Unravelling the Functional Diversity of Type III Polyketide Synthases in Fungi.Angewandte Chemie (International ed. in English) · 2025Article
- Identification of two new flavone 4'-Synthetic and systems biotechnology · 2025Article
- Integrated transcriptomic and metabolomic analysis unveils heat-tolerance-associated flavonoid metabolites and genes in the rice rel1-D mutant.BMC genomics · 2025Article
- Insights into a water-mediated catalytic triad architecture in CE20 carbohydrate esterases.Nature communications · 2025Article
- Evaluation of pigment composition and antioxidant properties in the flesh of seven colored pummelo cultivars.Food chemistry: X · 2025Article
- Structural and Interactional Analysis of the Flavonoid Pathway Proteins: Chalcone Synthase, Chalcone Isomerase and Chalcone Isomerase-like Protein.International journal of molecular sciences · 2024Article
- Engineering a Plant Polyketide Synthase for the Biosynthesis of Methylated Flavonoids.Journal of agricultural and food chemistry · 2024Article
- Heterologous Naringenin Production in the Filamentous FungusJournal of agricultural and food chemistry · 2023Article
- Microbial production of the plant flavanone hesperetin from caffeic acid.BMC research notes · 2023Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Homoeriodictyol and hesperetin are naturally occurring O-methylated flavonoids with many health-promoting properties. They are produced in plants in low abundance and as complex mixtures of similar compounds that are difficult to separate. Synthetic biology offers the opportunity to produce various flavonoids in a targeted, bottom-up approach in engineered microbes with high product titers. However, the production of O-methylated flavonoids is currently still highly inefficient. In this study, we investigated and engineered a combination of enzymes that had previously been shown to support homoeriodictyol and hesperetin production in
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