Evidence map›Paper›PMID 38109670›Full record

ReviewRheumatology (Oxford, England)2024

Lymphadenopathy in the rheumatology practice: a pragmatic approach.

Stefano Rodolfi, Emanuel Della-Torre, Lucia Bongiovanni, Puja Mehta, David C Fajgenbaum, Carlo Selmi

Abstract readReview
In one paragraph

Review in Rheumatology (Oxford, England), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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  15. Identifying Castleman disease from non-clonal inflammatory causes of generalized lymphadenopathy.Hematology. American Society of Hematology. Education Program · 2024
    Review
  16. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Stefano RodolfiDepartment of Rheumatology and Clinical Immunology, IRCCS Humanitas Research Hospital, Milan, Italy.
Emanuel Della-TorreUniversità Vita-Salute San Raffaele, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Lucia BongiovanniUniversità Vita-Salute San Raffaele, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Puja MehtaDivision of Medicine, University College, Centre for Inflammation and Tissue Repair, UCL Respiratory, London.ORCID 0000-0001-9459-9306
David C FajgenbaumDepartment of Medicine, Division of Translational Medicine and Human Genetics, Center for Cytokine Storm Treatment and Laboratory, Philadelphia, PA, USA.
Carlo SelmiDepartment of Rheumatology and Clinical Immunology, IRCCS Humanitas Research Hospital, Milan, Italy.ORCID 0000-0002-0323-0376

Funding

mTOR as a Central Regulator of iMCD Pathogenesis and Novel Therapeutic TargetR01HL141408 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI Taku Kambayashi · 2018 to 2026
$6.1M
ACCELERATE: An Efficient and Innovative Natural History Study Addressing Unmet Needs in Castleman DiseaseR01FD007632 · FDA · UNIVERSITY OF PENNSYLVANIA · PI Joshua D. Brandstadter, David C Fajgenbaum · 2022 to 2026
$2.2M
BIBLIOSANBiomedical ResearchFDA HHS R01 FD007632GlaxoSmithKline Experimental Medicine Initiative to Explore New TherapiesMedical Research CouncilNational Institute for Health and Care ResearchNHLBI NIH HHS R01 HL141408
6 · The paper itself

Abstract

Lymphadenopathy is a common clinical finding and diagnostic challenge within general medicine and rheumatology practice. It may represent a primary manifestation of an underlying immune-mediated disease or indicate an infectious or neoplastic complication requiring differing management. Evaluating lymphadenopathy is of particular relevance in rheumatology, given that lymph node enlargement is a common finding within the clinical spectrum of several well-known rheumatologic disorders including RA, SLE and SS. In addition, lymphadenopathy represents a hallmark manifestation of rare immunological diseases such as Castleman disease and IgG4-related disease that must be considered in the differential diagnosis because effective targeted treatments can now impact the prognosis of these conditions. In this review we present an overview of the clinical significance of lymphadenopathy in common and rare rheumatologic diseases and propose a practical approach to lymphadenopathy in the rheumatology practice. Differential diagnosis of Castleman disease and therapeutic options for this condition of increasing rheumatologic interest will be discussed in detail.

Indexed as

LymphadenopathyRheumatic DiseasesCastleman DiseaseDiagnosis, DifferentialHumansRheumatologyarthritisCastleman diseaseconnective tissue diseaseIgG4-related diseaselymph node enlargementsarcoidosissiltuximab

Identifiers

PMID38109670
PMCPMC11147542

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.