ArticleProceedings of the National Academy of Sciences of the United States of America2023
A distinct human cell type expressing MHCII and RORγt with dual characteristics of dendritic cells and type 3 innate lymphoid cells.
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Article in Proceedings of the National Academy of Sciences of the United States of America, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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29citing papers in PubMed
6.2field-weighted citation impact, top 3% of its field
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Who cites it
29 citing papers in PubMed, 38 citations in OpenAlex.
- Dysbiosis-induced expansion of AXL-positive inflammatory type 3 dendritic cells triggers preclinical autoimmunity.Nature immunology · 2026Article
- Innate lymphoid cells in rheumatoid arthritis as mediators of pathology and resolution.Nature reviews. Rheumatology · 2026Review
- Pan-cancer single-cell atlases of mouse and human tumor-associated dendritic cells.Nature communications · 2026Article
- Age- and tissue-dependent diversity of human plasmacytoid dendritic cells uncovers a cycling subset dominant in early life and cancer.Immunity · 2026Article
- Article
- RORγtScience immunology · 2026Article
- Alterations of circulating innate lymphoid cells in recent-onset type 1 diabetes.Clinical & translational immunology · 2026Article
- Plasticity and antigen presentation by group 3 innate lymphoid cells in colorectal cancer.Frontiers in immunology · 2026Review
- Specialized Dendritic Cells Mediating Peripheral Tolerance to Intestinal Antigens.Immunological reviews · 2026Review
- The normal human lymph node cell classification and landscape defined by high-dimensional spatial proteomics.PloS one · 2026Article
- Heterogeneity of the intestinal mononuclear phagocyte compartment in health and inflammatory bowel disease.Science immunology · 2025Article
- Single-cell multiomics data integration and generation with scPairing.Cell reports methods · 2025Article
- IFN-γ signaling stimulates intestinal crypt hyperplasia in celiac disease.The Journal of clinical investigation · 2025Article
- Microbiota-mediated mechanisms of mucosal immunity across the lifespan.Nature immunology · 2025Review
- RORγt eTACs mediate oral tolerance and Treg induction.The Journal of experimental medicine · 2025Article
- Thetis cells: regulators of intestinal immune tolerance.Current opinion in immunology · 2025Review
- A wave of Thetis cells imparts tolerance to food antigens early in life.Science (New York, N.Y.) · 2025Article
- The dual nature of TFEBS letters · 2025Review
- Review
- Article
Corrections and comments
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Authors and funding
25 authors at 10 institutions in 4 countries.
Alina Ulezko Antonova *Department of Pathology and Immunology, Washington University School of Medicine, Saint Louis, MO 63110.
Silvia Lonardi *Department of Molecular and Translational Medicine, University of Brescia, Brescia 25125, Italy.
Matilde MontiDepartment of Molecular and Translational Medicine, University of Brescia, Brescia 25125, Italy.
Francesco MissaleDepartment of Molecular and Translational Medicine, University of Brescia, Brescia 25125, Italy.
Changxu FanDepartment of Genetics, Washington University School of Medicine, Saint Louis, MO 63110.
Matthew L CoatesMolecular Immunity Unit, Department of Medicine, University of Cambridge, Cambridge CB2 0QH, United Kingdom.
Mattia BugattiDepartment of Molecular and Translational Medicine, University of Brescia, Brescia 25125, Italy.
Natalia JaegerDepartment of Pathology and Immunology, Washington University School of Medicine, Saint Louis, MO 63110.
Patrick Fernandes RodriguesDepartment of Pathology and Immunology, Washington University School of Medicine, Saint Louis, MO 63110.
Simone BrioschiDepartment of Pathology and Immunology, Washington University School of Medicine, Saint Louis, MO 63110.
Tihana TrsanDepartment of Pathology and Immunology, Washington University School of Medicine, Saint Louis, MO 63110.
José L FachiDepartment of Pathology and Immunology, Washington University School of Medicine, Saint Louis, MO 63110.
Khai M NguyenDepartment of Pathology and Immunology, Washington University School of Medicine, Saint Louis, MO 63110.
Ryan M NunleyWashington University Orthopedics, Barnes Jewish Hospital, Saint Louis, MO 63110.
Daniele MorattoDepartment of Lab Diagnostics, Azienda Socio Sanitaria Territoriale Spedali Civili di Brescia, Brescia 25100, Italy.
Stefania ZiniDepartment of Molecular and Translational Medicine, University of Brescia, Brescia 25125, Italy.
Lingjia KongImmunology Program, Broad Institute of Massachussets Institute of Technology and Harvard, Cambridge, MA 02142.
Jacques DeguineCenter for Computational and Integrative Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114.ORCID 0000-0001-9218-3040
Mark E PeeplesInfectious Diseases Institute, The Ohio State University, Columbus, OH 43210.ORCID 0000-0002-4582-317X
Ramnik J XavierImmunology Program, Broad Institute of Massachussets Institute of Technology and Harvard, Cambridge, MA 02142.
Menna R ClatworthyMolecular Immunity Unit, Department of Medicine, University of Cambridge, Cambridge CB2 0QH, United Kingdom.
Ting WangDepartment of Genetics, Washington University School of Medicine, Saint Louis, MO 63110.
Marina CellaDepartment of Pathology and Immunology, Washington University School of Medicine, Saint Louis, MO 63110.ORCID 0000-0003-1230-1313
William VermiDepartment of Pathology and Immunology, Washington University School of Medicine, Saint Louis, MO 63110.ORCID 0000-0002-2291-2997
Marco ColonnaDepartment of Pathology and Immunology, Washington University School of Medicine, Saint Louis, MO 63110.ORCID 0000-0001-5222-4987
Washington University in St. Louis · USUniversity of Brescia · ITBroad Institute · USAzienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia · ITBarnes-Jewish Hospital · USHarvard University · USNational Health Service · GBNationwide Children's Hospital · USThe Netherlands Cancer Institute · NLUniversity of Cambridge · GB
Funding
Washington University Center for Cellular ImagingP30CA091842 · NCI · WASHINGTON UNIVERSITY · PI TIMOTHY J. EBERLEIN · 2001 to 2026
$128.0MWU INSTITUTE OF CLINICAL AND TRANSLATIONAL SCIENCESUL1TR002345 · NCATS · WASHINGTON UNIVERSITY · PI William G. Powderly · 2017 to 2026
$97.8MPilot & Feasibility ProgramP30DK043351 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI Ramnik J Xavier · 1991 to 2026
$35.3MWashington University DDRCC Supplemental Equipment RequestP30DK052574 · NIDDK · WASHINGTON UNIVERSITY · PI Jeffrey Wade Brown · 2000 to 2026
$30.8MTechnology Development Project - Increasing the complexity of ex vivo human airway models for studying immune response to viral infectionU19AI142733 · NIAID · JACKSON LABORATORY · PI Anna Karolina Palucka · 2019 to 2026
$23.1MCIS-REGULATORY CIRCUITS FOR ILC FUNCTION AND PLASTICITYR01AI134035 · NIAID · WASHINGTON UNIVERSITY · PI MARCO COLONNA, Eugene M Oltz · 2018 to 2026
$4.8MMucosal Immune Defense Mechanisms of the Urinary BladderR01DK132327 · NIDDK · WASHINGTON UNIVERSITY · PI MARCO COLONNA, SCOTT J. HULTGREN · 2023 to 2026
$2.5MMICROBIOTA-DEPENDENT CONTROL OF CLOSTRIDIUM DIFFICILE: THE ROLE OF ACETATE AND IL-22 BINDING PROTEINR01DK126969 · NIDDK · WASHINGTON UNIVERSITY · PI COLONNA, MARCO · 2021 to 2024
$1.6MPlasticity of Innate Lymphoid Cells: Mechanisms and Biological ImpactR01DK124699 · NIDDK · WASHINGTON UNIVERSITY · PI COLONNA, MARCO · 2020 to 2023
$1.4MNCATS NIH HHS UL1 TR002345NCI NIH HHS P30 CA091842NIAID NIH HHS R01 AI134035NIAID NIH HHS U19 AI142733NIDDK NIH HHS P30 DK043351NIDDK NIH HHS P30 DK052574NIDDK NIH HHS R01 DK124699NIDDK NIH HHS R01 DK126969NIDDK NIH HHS R01 DK132327
Abstract
Recent studies have characterized various mouse antigen-presenting cells (APCs) expressing the lymphoid-lineage transcription factor RORγt (Retinoid-related orphan receptor gamma t), which exhibit distinct phenotypic features and are implicated in the induction of peripheral regulatory T cells (Tregs) and immune tolerance to microbiota and self-antigens. These APCs encompass Janus cells and Thetis cell subsets, some of which express the AutoImmune REgulator (AIRE). RORγt
Indexed as
Immunity, InnateLymphocytesAnimalsDendritic CellsHumansInflammationMiceNuclear Receptor Subfamily 1, Group F, Member 3Nuclear Receptor Subfamily 1, Group F, Member 3antigen presentationdendritic cellshumaninnate lymphoid cellsretinoid-related orphan receptor gamma t
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.