Evidence map›Paper›PMID 38109430›Full record

ArticlePloS one2023

Normalization in mouse primary visual cortex.

Zaina A Zayyad, John H R Maunsell, Jason N MacLean

Abstract read
In one paragraph

Article in PloS one, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Neuronal normalization in monkey MT is an intensity-weighted average.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  2. Neuronal normalization in monkey MT is an intensity-weighted average.bioRxiv : the preprint server for biology · 2025
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

Zaina A ZayyadInterdisciplinary Scientist Training Program, University of Chicago Pritzker School of Medicine, Chicago, IL, United States of America.ORCID 0000-0002-5430-112X
John H R MaunsellCommittee on Computational Neuroscience, University of Chicago, Chicago, IL, United States of America.ORCID 0000-0003-0018-4439
Jason N MacLeanCommittee on Computational Neuroscience, University of Chicago, Chicago, IL, United States of America.ORCID 0000-0002-8021-8063

Funding

MEDICAL SCIENTIST TRAININGT32GM007281 · NIGMS · UNIVERSITY OF CHICAGO · PI CLARK, MARCUS RAMSAY · 1985 to 2022
$32.1M
Readout and control of spatiotemporal neuronal codes for behaviorU19NS107464 · NINDS · UNIVERSITY OF CHICAGO · PI BABADI, BEHTASH, CHIALVO, DANTE R · 2018 to 2022
$17.3M
Functional relationships between visual cortex and thalamusR01EY022338 · NEI · UNIVERSITY OF CHICAGO · PI SHERMAN, S. MURRAY · 2012 to 2020
$3.6M
The origins of neuronal correlations in cerebral cortexRF1NS121772 · NINDS · UNIVERSITY OF CHICAGO · PI HEEGER, DAVID J, MACLEAN, JASON NEIL · 2021 to 2021
$2.0M
The origins of neuronal correlations in cerebral cortexR01NS121772 · NINDS · UNIVERSITY OF CHICAGO · PI HEEGER, DAVID J, MACLEAN, JASON NEIL · 2024 to 2025
$1.4M
Excitatory and Inhibitory Mechanisms of Divisive Normalization in Mouse V1F30EY030733 · NEI · UNIVERSITY OF CHICAGO · PI ZAYYAD, ZAINA ADEL · 2020 to 2021
$102k
NEI NIH HHS F30 EY030733NEI NIH HHS R01 EY022338NIGMS NIH HHS T32 GM007281NINDS NIH HHS R01 NS121772NINDS NIH HHS RF1 NS121772NINDS NIH HHS U19 NS107464
6 · The paper itself

Abstract

When multiple stimuli appear together in the receptive field of a visual cortical neuron, the response is typically close to the average of that neuron's response to each individual stimulus. The departure from a linear sum of each individual response is referred to as normalization. In mammals, normalization has been best characterized in the visual cortex of macaques and cats. Here we study visually evoked normalization in the visual cortex of awake mice using imaging of calcium indicators in large populations of layer 2/3 (L2/3) V1 excitatory neurons and electrophysiological recordings across layers in V1. Regardless of recording method, mouse visual cortical neurons exhibit normalization to varying degrees. The distributions of normalization strength are similar to those described in cats and macaques, albeit slightly weaker on average.

Indexed as

Primary Visual CortexVisual CortexAnimalsCatsMacacaMammalsMiceNeuronsPhotic Stimulation

Identifiers

PMID38109430
PMCPMC10727357

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.