Evidence map›Paper›PMID 38109372›Full record

ArticleJournal of the Chinese Medical Association : JCMA2024

Ganoderma lucidum spore oil synergistically enhances the function of cyclophosphamide in the prevention of breast cancer metastasis.

Shu Lian, Wulin Li, Chunlian Zhong, Ye Li, Changhui Wu, Kun Zhang, Jiangfei Lin, Weiyu Wang, Vladimir Katanaev, Xiaodong Xie and 1 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the Chinese Medical Association : JCMA, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.7field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
  3. CanPharmaceuticals (Basel, Switzerland) · 2025
    Review
  4. Article
  5. Ethanolic Extract ofPharmaceuticals (Basel, Switzerland) · 2025
    Article
  6. Review
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

Shu LianFujian-Taiwan-Hongkong-Macao Science and Technology Cooperation Base of Intelligent Pharmaceutics, Institute of Oceanography, College of Materials and Chemical Engineering, Minjiang University, Fuzhou, Fujian, China.
Wulin LiInstitute of Chemisty, Fuzhou University, Fuzhou, Fujian, China.
Chunlian ZhongFujian-Taiwan-Hongkong-Macao Science and Technology Cooperation Base of Intelligent Pharmaceutics, Institute of Oceanography, College of Materials and Chemical Engineering, Minjiang University, Fuzhou, Fujian, China.
Ye LiFujian Xianzhilou Biological and Technology Co., Ltd., Fuzhou, Fujian, China.
Changhui WuFujian Xianzhilou Biological and Technology Co., Ltd., Fuzhou, Fujian, China.
Kun ZhangFujian Xianzhilou Biological and Technology Co., Ltd., Fuzhou, Fujian, China.
Jiangfei LinFujian-Taiwan-Hongkong-Macao Science and Technology Cooperation Base of Intelligent Pharmaceutics, Institute of Oceanography, College of Materials and Chemical Engineering, Minjiang University, Fuzhou, Fujian, China.
Weiyu WangFujian-Taiwan-Hongkong-Macao Science and Technology Cooperation Base of Intelligent Pharmaceutics, Institute of Oceanography, College of Materials and Chemical Engineering, Minjiang University, Fuzhou, Fujian, China.
Vladimir KatanaevFaculty of Medicine, Department of Cell Physiology and Metabolism, Translational Research Center in Oncohaematology, University of Geneva, Geneva, Switzerland.
Xiaodong XieFujian-Taiwan-Hongkong-Macao Science and Technology Cooperation Base of Intelligent Pharmaceutics, Institute of Oceanography, College of Materials and Chemical Engineering, Minjiang University, Fuzhou, Fujian, China.
Lee JiaFujian-Taiwan-Hongkong-Macao Science and Technology Cooperation Base of Intelligent Pharmaceutics, Institute of Oceanography, College of Materials and Chemical Engineering, Minjiang University, Fuzhou, Fujian, China.
Minjiang University · CNFuzhou University · CNUniversity of Geneva · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundGanoderma lucidum ( G . lucidum ) is a traditional Chinese herbal medicine that has shown potential as an alternative adjuvant therapy for cancer patients. However, the mechanisms and adjuvant therapeutic effects of G . lucidum in cancer treatment remain unclear.

methodsIn this work, G . lucidum spore oil (GanoOil), a newly developed oily G . lucidum spore extract was used to investigate the mechanisms and adjuvant therapeutic effects of GanoOil in conjunction with the chemotherapeutic drug cyclophosphamide (CTX) for preventing breast cancer metastasis.

resultsIn the model of lung metastasis, orally administered GanoOil increased the population of CD8 + T cells and interleukin (IL)-6 cytokine levels in mouse blood, whereas also enhancing the activity of natural killer cells in the spleen. Furthermore, the combination of GanoOil and CTX effectively suppressed the lung metastasis of circulating breast cancer cells, alleviated CTX-induced weight loss, and reduced the ratio of lung and spleen weight to body weight in mice. Moreover, high concentrations of GanoOil exhibited no significant toxicity or side effects in both in vitro and in vivo experiments.

conclusionIn conclusion, GanoOil is a safe drug that can enhance immune activity in mice to achieve therapeutic effects on cancer, and can also synergistically inhibit tumor metastasis with CTX.

Indexed as

Breast NeoplasmsLung NeoplasmsNeoplasms, Second PrimaryReishiAnimalsCyclophosphamideFemaleHumansInterleukin-6MiceSpores, FungalCyclophosphamideInterleukin-6

Identifiers

PMID38109372
PMCPMC12718809
OpenAlexW4389879893

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.