Evidence map›Paper›PMID 38109334›Full record

ArticleJournal of addiction medicine

The IMPACT (Infection Management Plus Addiction Care Together) Pilot: A Case Series of Combined Contingency Management for Substance Use Disorders and Antibiotic Adherence in the Hospital Setting.

Ayesha Appa, Stefan Baral, Brianna Stein, Kelly Knight, Monica Gandhi, Phillip Coffin, Marlene Martin

Open access · greenAbstract read
In one paragraph

Article in Journal of addiction medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Article
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  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Ayesha AppaFrom the Department of Medicine, University of California, San Francisco, San Francisco, CA (AA, KK, MG, MM); Department of Epidemiology, Johns Hopkins University, Baltimore, MD (SB); Department of Family and Community Medicine, University of California, San Francisco, San Francisco, CA (BS); San Francisco Department of Public Health, San Francisco, CA (PC).
Stefan Baral
Brianna Stein
Kelly Knight
Monica Gandhi
Phillip Coffin
Marlene Martin
University of California, San Francisco · US

Funding

Vaccine Response and Immunotherapeutics SWGP30AI094189 · NIAID · JOHNS HOPKINS UNIVERSITY · PI Anna Palmer Durbin · 2012 to 2026
$67.0M
Training in HIV Translational ResearchT32AI060530 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Diane V Havlir · 2005 to 2026
$6.4M
Pharmacology and Pharmacometrics CoreP30AI168436 · NIAID · JOHNS HOPKINS UNIVERSITY · PI MAUNANK SHAH · 2022 to 2026
$6.1M
“Hair Lengthening”: Using Hair Levels to Interpret Long-Acting PrEP Studies.R37AI098472 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Monica Gandhi · 2023 to 2026
$3.2M
University of California, San Francisco/Kaiser Permanente Northern California Division of Research Building Interdisciplinary Research Careers in Women’s Health (BIRCWH) K12 ProgramK12AR084219 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Monica Gandhi, CYNTHIA C HARPER · 2023 to 2026
$3.1M
Unraveling the intersection of substance use, inflammation, and HIV via hair levelsR01DA059291 · NIDA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Monica Gandhi, Pamina Mae Gorbach · 2023 to 2026
$3.0M
Midcareer K24 Award for Mentoring and Patient-Oriented ResearchK24DA042720 · NIDA · SAN FRANCISCO DEPARTMENT OF PUBLIC HEALTH · PI PHILLIP O COFFIN · 2016 to 2026
$1.6M
NIAID NIH HHS P30 AI094189NIAID NIH HHS P30 AI168436NIAID NIH HHS R37 AI098472NIAID NIH HHS T32 AI060530NIAMS NIH HHS K12 AR084219NIDA NIH HHS K24 DA042720NIDA NIH HHS R01 DA059291
6 · The paper itself

Abstract

objectivesPsychostimulant-related mortality is rising alongside increasing substance use-related hospitalizations, which are commonly complicated by patient-directed (or "against medical advice") discharges. Contingency management (CM) is an underused evidence-based treatment for substance use disorders with proven efficacy to support medication adherence. Our objective was to describe feasibility and preliminary effectiveness of a novel CM intervention incentivizing both drug use reduction and antibiotic adherence in the hospital setting.

methodsWe conducted a pilot intervention of twice weekly CM for stimulant and/or opioid use disorder and antibiotic adherence conducted on inpatient wards and/or an embedded skilled nursing facility in an urban public hospital. Based on point-of-care urine drug test results and objective antibiotic adherence review, participants earned increasing opportunities to receive incentives. We measured feasibility via number of visits attempted and cost of gift cards dispensed. We evaluated effectiveness via antibiotic completion, discharge type, and participant perception of intervention effectiveness collected via structured survey.

resultsOf 13 participants enrolled, most had opioid use disorder (fentanyl in 10/13) and stimulant use disorder (methamphetamine in 7/13). Almost all were receiving treatment for osteomyelitis and/or endocarditis (12/13). Feasibility challenges included competing demands of acute care with variable range of completed visits per participant (1-12 visits). Despite this, antibiotic completion was high (92%, 12/13 participants) with only two patient-directed discharges. Participants described CM as very effective in aiding infection treatment but had greater variability in beliefs regarding CM facilitation of reduced drug use.

conclusionsProviding CM in the hospital setting may represent an effective approach to improving health outcomes by increasing antibiotic adherence and addressing substance use.

Indexed as

Central Nervous System StimulantsMethamphetamineOpioid-Related DisordersBehavior TherapyHospitalsHumansCentral Nervous System StimulantsMethamphetamine

Identifiers

PMID38109334
PMCPMC10939948
OpenAlexW4389924790

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.