Evidence map›Paper›PMID 38108844›Full record

ArticleAnalytical and bioanalytical chemistry2024

A liquid chromatography-mass spectrometry method for the enantioselective multiresidue determination of nine chiral agrochemicals in urine using an enrichment procedure based on graphitized carbon black.

Elena Lucci, Lorenzo Antonelli, Monica Gherardi, Chiara Fanali, Salvatore Fanali, Anita Scipioni, Paolo Lupattelli, Alessandra Gentili, Bezhan Chankvetadze

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Article in Analytical and bioanalytical chemistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

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3citing papers in PubMed
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1 · What the graph read from it

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3 · Its place in the literature

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3 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Elena LucciDepartment of Chemistry, Sapienza University, Rome, Italy.
Lorenzo AntonelliDepartment of Chemistry, Sapienza University, Rome, Italy.
Monica GherardiINAIL-DiMEILA, Chemical Risk Laboratory, Monte Porzio Catone Research Centre, Rome, Italy.
Chiara FanaliDepartment of Science and Technology for Humans and the Environment, University Campus Bio-Medico of Rome, Rome, Italy.
Salvatore FanaliSchool in Nanoscience and Advanced Technologies, University of Verona, Verona, Italy.
Anita ScipioniDepartment of Chemistry, Sapienza University, Rome, Italy.
Paolo LupattelliDepartment of Chemistry, Sapienza University, Rome, Italy.
Alessandra GentiliDepartment of Chemistry, Sapienza University, Rome, Italy. alessandra.gentili@uniroma1.it.
Bezhan ChankvetadzeInstitute of Physical and Analytical Chemistry, School of Exact and Natural Sciences, Tbilisi State University, Tbilisi, Georgia.

Funding

Sapienza University of Rome, Start-up research project AR1221814C70F4A4
6 · The paper itself

Abstract

Many agrochemicals are chiral molecules, and most of them are marketed as racemates or diastereomeric mixtures. Stereoisomers that are not the active enantiomer have little or no pesticidal activity and can exert serious toxic effects towards non-target organisms. Thus, investigating the possible exposure to different isomers of chiral pesticides is an urgent need. The present work was aimed at developing a new enantioselective high-performance liquid chromatography-mass spectrometry method for the simultaneous determination of nine chiral pesticides in urine. Two solid-phase extraction (SPE) procedures, based on different carbon-based sorbents (graphitized carbon black (GCB) and buckypaper (BP)), were developed and compared. By using GCB, all analytes were recovered with yields ranging from 60 to 97%, while BP allowed recoveries greater than 54% for all pesticides except those with acid characteristics. Baseline separation was achieved for the enantiomers of all target agrochemicals on a Lux Cellulose-2 column within 24 min under reversed-phase mode. The developed method was then validated according to the FDA guidelines for bioanalytical methods. Besides recovery, the other evaluated parameters were precision (7-15%), limits of detection (0.26-2.21 µg/L), lower limits of quantitation (0.43-3.68 µg/L), linear dynamic range, and sensitivity. Finally, the validated method was applied to verify the occurrence of the pesticide enantiomers in urine samples from occupationally exposed workers.

Indexed as

AgrochemicalsPesticidesChromatography, High Pressure LiquidHumansLiquid Chromatography-Mass SpectrometrySolid Phase ExtractionSootStereoisomerismTandem Mass SpectrometryAgrochemicalsPesticidesSootCarbon-based sorbentsChiral pesticidesEnantioselective separationsHPLC–MS/MSSolid-phase extractionUrine

Identifiers

PMID38108844

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.