Evidence map›Paper›PMID 38108557›Full record

ArticleMolecular oral microbiology2024

Activation of liver X receptors suppresses the abundance and osteoclastogenic potential of osteoclast precursors and periodontal bone loss.

Yanfang Zhao, Kai Yang, Thalyta Amanda Ferreira, Xuejia Kang, Xu Feng, Jannet Katz, Suzanne M Michalek, Ping Zhang

Open access · hybridAbstract read
In one paragraph

Article in Molecular oral microbiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Yanfang ZhaoDepartment of Pediatric Dentistry, School of Dentistry, University of Alabama at Birmingham, Birmingham, Alabama, USA.ORCID 0000-0003-4126-1955
Kai YangDepartment of Pediatric Dentistry, School of Dentistry, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Thalyta Amanda FerreiraDepartment of Pediatric Dentistry, School of Dentistry, University of Alabama at Birmingham, Birmingham, Alabama, USA.ORCID 0000-0001-7247-6559
Xuejia KangDepartment of Drug Discovery and Development, Harrison College of Pharmacy, Auburn University, Auburn, Alabama, USA.
Xu FengDepartment of Pathology, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Jannet KatzDepartment of Pediatric Dentistry, School of Dentistry, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Suzanne M MichalekDepartment of Microbiology, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Ping ZhangDepartment of Pediatric Dentistry, School of Dentistry, University of Alabama at Birmingham, Birmingham, Alabama, USA.
University of Alabama at Birmingham · USAuburn University · US

Funding

ROS Modulation of Innate and Adaptive Immunity in RAP30AR048311 · NIAMS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI MOUNTZ, JOHN D · 2001 to 2017
$9.5M
ROLE OF OSTEOCLAST PRECURSORS IN PERIODONTAL BONE LOSSR01DE026465 · NIDCR · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI ZHANG, PING · 2017 to 2021
$2.1M
IMPORTANCE OF PERIODONTITIS IN THE INNATE IMMUNE REGULATION OF ALZHEIMER'S DISEASER01AG078708 · NIA · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Ping Zhang · 2023 to 2026
$1.5M
WOMEN'S HEALTH AGENDAU01AI027667 · NIAID · MOUNT SINAI SCHOOL OF MEDICINE OF NYU · PI SACKS, HENRY S · 1988 to 2001
$1.0M
Dental Academic Research Training Program (DART)R90DE023056 · NIDCR · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Amjad Javed · 2012 to 2026
$913k
NIAMS NIH HHS P30 AR048311NIA NIH HHS R01 AG078708NIDCR NIH HHS R01 DE026465NIDCR NIH HHS R90 DE023056NIH HHS P30AI27667NIH HHS P30AR048311
6 · The paper itself

Abstract

Liver-X receptors (LXRs) are essential nuclear hormone receptors involved in cholesterol and lipid metabolism. They are also believed to regulate inflammation and physiological and pathological bone turnover. We have previously shown that infection with the periodontal pathogen Porphyromonas gingivalis (Pg) in mice increases the abundance of CD11b

Indexed as

Alveolar Bone LossLiver X ReceptorsOsteoclastsPorphyromonas gingivalisAnimalsBacteroidaceae InfectionsBenzylaminesCD11b AntigenDown-RegulationMaleMiceMice, Inbred C57BLPeriodontitisBenzylaminesCD11b AntigenLiver X Receptorsliver X receptorsosteoclast precursorsperiodontitisPorphyromonas gingivalis

Identifiers

PMID38108557
PMCPMC11096071
OpenAlexW4389900033

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.