Evidence map›Paper›PMID 38108518›Full record

ArticleThe CRISPR journal2023

Engineered Antiviral Sensor Targets Infected Mosquitoes.

Elena Dalla Benetta, Adam J López-Denman, Hsing-Han Li, Reem A Masri, Daniel J Brogan, Michelle Bui, Ting Yang, Ming Li, Michael Dunn, Melissa J Klein and 8 more

Open access · greenAbstract read
In one paragraph

Article in The CRISPR journal, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 19 citations in OpenAlex.

  1. Review
  2. Review
  3. Horizons of the Future: Preparedness and Response.Current topics in microbiology and immunology · 2026
    Review
  4. Article
  5. ExploitingPathogens (Basel, Switzerland) · 2025
    Review
  6. Article
  7. Article
  8. Article
  9. Review
  10. Review
  11. Article
  12. Review
  13. Review
  14. Article
  15. Targeting Sex Determination to Suppress Mosquito Populations.bioRxiv : the preprint server for biology · 2023
    Article
  16. Article
  17. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

18 authors at 4 institutions in 3 countries.

Elena Dalla BenettaDepartment of Cell and Developmental Biology, School of Biological Sciences, University of California, San Diego, La Jolla, California, USA.ORCID 0000-0003-2556-8500
Adam J López-DenmanCSIRO Health and Biosecurity, Australian Centre for Disease Preparedness, Geelong, Australia.
Hsing-Han LiDepartment of Cell and Developmental Biology, School of Biological Sciences, University of California, San Diego, La Jolla, California, USA.
Reem A MasriDepartment of Cell and Developmental Biology, School of Biological Sciences, University of California, San Diego, La Jolla, California, USA.
Daniel J BroganDepartment of Cell and Developmental Biology, School of Biological Sciences, University of California, San Diego, La Jolla, California, USA.
Michelle BuiDepartment of Cell and Developmental Biology, School of Biological Sciences, University of California, San Diego, La Jolla, California, USA.
Ting YangDepartment of Cell and Developmental Biology, School of Biological Sciences, University of California, San Diego, La Jolla, California, USA.ORCID 0000-0001-7201-4231
Ming LiDepartment of Cell and Developmental Biology, School of Biological Sciences, University of California, San Diego, La Jolla, California, USA.
Michael DunnCSIRO Health and Biosecurity, Australian Centre for Disease Preparedness, Geelong, Australia.
Melissa J KleinCSIRO Health and Biosecurity, Australian Centre for Disease Preparedness, Geelong, Australia.
Sarah JacksonCSIRO Health and Biosecurity, Australian Centre for Disease Preparedness, Geelong, Australia.
Kyle CatalanCSIRO Health and Biosecurity, Australian Centre for Disease Preparedness, Geelong, Australia.ORCID 0000-0003-4414-8608
Kim R BlasdellCSIRO Health and Biosecurity, Australian Centre for Disease Preparedness, Geelong, Australia.
Priscilla TngArthropod Genetics, The Pirbright Institute, Pirbright, United Kingdom.
Igor AntoshechkinDivision of Biology and Biological Engineering (BBE), California Institute of Technology, Pasadena, California, USA.
Luke S AlpheyArthropod Genetics, The Pirbright Institute, Pirbright, United Kingdom.
Prasad N ParadkarCSIRO Health and Biosecurity, Australian Centre for Disease Preparedness, Geelong, Australia.
Omar S AkbariDepartment of Cell and Developmental Biology, School of Biological Sciences, University of California, San Diego, La Jolla, California, USA.ORCID 0000-0002-6853-9884
University of California San Diego · USAustralian Centre for Disease Preparedness · AUThe Pirbright Institute · GBCalifornia Institute of Technology · US

Funding

The olfactory basis of locating nectar sugar sources in Aedes aegypti mosquitoesR01AI148300 · NIAID · UNIVERSITY OF WASHINGTON · PI Omar Sultan Akbari, Ronald Jason Pitts · 2021 to 2026
$4.1M
Development of synthetic viral circuitry to regulate viruses in mosquito disease vectorsDP2AI152071 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI AKBARI, OMAR SULTAN · 2019 to 2019
$2.4M
Precision guided SIT for the control of vector-borne diseaseR01AI151004 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI AKBARI, OMAR SULTAN · 2020 to 2024
$2.3M
Development of synthetic gene drives using small moleculesR01GM132825 · NIGMS · BRIGHAM AND WOMEN'S HOSPITAL · PI AKBARI, OMAR SULTAN, CHOUDHARY, AMIT · 2019 to 2022
$1.4M
Transcriptome engineering technologies for the development of antiviral effectors in mosquitoesR21AI149161 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI AKBARI, OMAR SULTAN · 2020 to 2021
$434k
NIAID NIH HHS DP2 AI152071NIAID NIH HHS R01 AI148300NIAID NIH HHS R01 AI151004NIAID NIH HHS R21 AI149161NIGMS NIH HHS R01 GM132825
6 · The paper itself

Abstract

Escalating vector disease burdens pose significant global health risks, as such innovative tools for targeting mosquitoes are critical. CRISPR-Cas technologies have played a crucial role in developing powerful tools for genome manipulation in various eukaryotic organisms. Although considerable efforts have focused on utilizing class II type II CRISPR-Cas9 systems for DNA targeting, these modalities are unable to target RNA molecules, limiting their utility against RNA viruses. Recently, the Cas13 family has emerged as an efficient tool for RNA targeting; however, the application of this technique in mosquitoes, particularly

Indexed as

CulicidaeAnimalsAntiviral AgentsCRISPR-Cas SystemsGene EditingMosquito VectorsRNA, ViralAntiviral AgentsRNA, Viral

Identifiers

PMID38108518
PMCPMC11085028
OpenAlexW4389899937

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.