Evidence map›Paper›PMID 38108436›Full record

ArticleHistology and histopathology2024

Differential roles of serotonin receptor subtypes in regulation of neurotrophin receptor expression and intestinal hypernociception.

Meng-Ping She, Yu-Ting Hsieh, Li-Yu Lin, Chia-Hung Tu, Ming-Shiang Wu, Ling-Wei Hsin, Linda Chia-Hui Yu

Abstract read
PubMed Publisher
In one paragraph

Article in Histology and histopathology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.4field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Emergence of invasiveGut microbes · 2026
    Article
  2. 5-HTThe Journal of physiology · 2025
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Meng-Ping SheGraduate Institute of Physiology, National Taiwan University College of Medicine, Taipei, Taiwan ROC.
Yu-Ting HsiehGraduate Institute of Physiology, National Taiwan University College of Medicine, Taipei, Taiwan ROC.
Li-Yu LinGraduate Institute of Physiology, National Taiwan University College of Medicine, Taipei, Taiwan ROC.
Chia-Hung TuDepartment of Internal Medicine, National Taiwan University Hospital and College of Medicine, Taipei, Taiwan ROC.
Ming-Shiang WuDepartment of Internal Medicine, National Taiwan University Hospital and College of Medicine, Taipei, Taiwan ROC.
Ling-Wei HsinSchool of Pharmacy, National Taiwan University, Taipei, Taiwan ROC.
Linda Chia-Hui YuGraduate Institute of Physiology, National Taiwan University College of Medicine, Taipei, Taiwan ROC. lchyu@ntu.edu.tw.
National Taiwan University · TWNational Taiwan University Hospital · TW

Funding

Ministry of Science and Technology MOST 110-2320-B-002-011-MY3Ministry of Science and Technology MOST 110-2622-B-002-013National Health Research Institutes NHRI-EX111/112/113-11108BINational Research Program for Biopharmaceuticals, National Science Council 101-2325-B-002-031National Research Program for Biopharmaceuticals, National Science Council 102-2325-B-002-030National Research Program for Biopharmaceuticals, National Science Council NSC100-2325-B-002-035National Science and Technology Council NSTC 111-2622-B-002-016National Taiwan University SPARK projects NTUCC-109L893102National Taiwan University SPARK projects NTUCC-110L891202National Taiwan University SPARK projects NTUCC-111L890602National Taiwan University SPARK projects NTU-CC-112L895002National Taiwan University SPARK projects NTU-CC-113L892702
6 · The paper itself

Abstract

objectivesAberrant serotonin (5-hydroxytryptamine, 5-HT) metabolism and neurite outgrowth were associated with abdominal pain in irritable bowel syndrome (IBS). We previously demonstrated that 5-HT receptor subtype 7 (5-HT₇) was involved in visceral hypersensitivity of IBS-like mouse models. The aim was to compare the analgesic effects of a novel 5-HT₇ antagonist to reference standards in mouse models and investigate the mechanisms of 5-HT₇-dependent neuroplasticity.

methodsTwo mouse models, including Giardia post-infection combined with water avoidance stress (GW) and post-resolution of trinitrobenzene sulfonic acid-induced colitis (PT) were used. Mice were orally administered CYY1005 (CYY, a novel 5-HT₇ antagonist), alosetron (ALN, a 5-HT₃ antagonist), and loperamide (LPM, an opioid receptor agonist) prior to measurement of visceromotor responses (VMR). Levels of nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), and neurotrophin receptors (NTRs) were assessed.

resultsPeroral CYY was more potent than ALN or LPM in reducing VMR values in GW and PT mice. Increased mucosal 5-HT₇-expressing nerve fibers were associated with elevated

conclusionsStronger analgesic effects by peroral CYY were observed compared with reference standards in two IBS-like mouse models. The 5-HT₇-dependent NTR upregulation and neurite elongation may be involved in intestinal hypernociception.

Indexed as

Receptors, SerotoninAnimalsColitisDisease Models, AnimalHumansIrritable Bowel SyndromeMaleMiceMice, Inbred C57BLSerotoninSerotonin AntagonistsReceptors, SerotoninSerotoninserotonin 7 receptorSerotonin Antagonists

Identifiers

PMID38108436
OpenAlexW4389899923

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.