Evidence map›Paper›PMID 38108041›Full record

ArticleMolecular syndromology2023

Detection of Modified Histones from Oral Mucosa of a Patient with DYT-

Naoto Sugeno, Takafumi Hasegawa, Kazuhiro Haginoya, Takafumi Kubota, Kensuke Ikeda, Takaaki Nakamura, Shun Ishiyama, Kazuki Sato, Shun Yoshida, Eriko Koshimizu and 4 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular syndromology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 1 country.

Naoto SugenoDepartment of Neurology, Tohoku University Graduate School of Medicine, Sendai, Japan.
Takafumi HasegawaDepartment of Neurology, Tohoku University Graduate School of Medicine, Sendai, Japan.
Kazuhiro HaginoyaDepartment of Pediatrics, Tohoku University School of Medicine, Sendai, Japan.
Takafumi KubotaDepartment of Neurology, Tohoku University Graduate School of Medicine, Sendai, Japan.
Kensuke IkedaDepartment of Neurology, Tohoku University Graduate School of Medicine, Sendai, Japan.
Takaaki NakamuraDepartment of Neurology, Tohoku University Graduate School of Medicine, Sendai, Japan.
Shun IshiyamaDepartment of Neurology, Tohoku University Graduate School of Medicine, Sendai, Japan.
Kazuki SatoDepartment of Neurology, Tohoku University Graduate School of Medicine, Sendai, Japan.
Shun YoshidaDepartment of Neurology, Tohoku University Graduate School of Medicine, Sendai, Japan.
Eriko KoshimizuDepartment of Human Genetics, Graduate School of Medicine, Yokohama City University, Yokohama, Japan.
Mitsugu UematsuDepartment of Pediatrics, Tohoku University School of Medicine, Sendai, Japan.
Satoko MiyatakeDepartment of Human Genetics, Graduate School of Medicine, Yokohama City University, Yokohama, Japan.
Naomichi MatsumotoDepartment of Human Genetics, Graduate School of Medicine, Yokohama City University, Yokohama, Japan.
Masashi AokiDepartment of Neurology, Tohoku University Graduate School of Medicine, Sendai, Japan.
Tohoku University · JPYokohama City University · JPYokohama City University Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: DYT- Methods: Histone proteins were purified from the oral mucosa of patients with de novo Results: H3K4me3 histone mark was markedly lower in the patient than in the control group. Additionally, a reanalysis of publicly available datasets concerning DNA methylation also demonstrated that Discussion: Although only one case was studied due to the rarity of the disease, the reduction of H3K4me3 in the patient's biological sample supports the dysfunction of KMT2B in DYT-

Indexed as

DYT28EpigenomeHereditary dystoniaKMT2BParkinsonism

Identifiers

PMID38108041
PMCPMC10722472
OpenAlexW4382046552

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.