Evidence map›Paper›PMID 38107948›Full record

ArticleACS omega2023

A Structural and

Mohanbabu Mookkan, Saravanan Kandasamy, Abdel-Basit Al-Odayni, Naaser Ahmed Yaseen Abduh, Sugarthi Srinivasan, Bistuvalli Chandrashekara Revannasidappa, Vasantha Kumar, Kalaiarasi Chinnasamy, Sanmargam Aravindhan, Madan Kumar Shankar

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In one paragraph

Article in ACS omega, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Mohanbabu MookkanDepartment of Physics, Presidency College (Autonomous), University of Madras, Chennai 600 005, India.
Saravanan KandasamyFaculty of Chemistry, University of Warsaw, Ludwika Pasteura 1, Warsaw 02-093, Poland.
Abdel-Basit Al-OdayniDepartment of Restorative Dental Science, College of Dentistry, King Saud University, P.O. Box 60169, Riyadh 11545, Saudi Arabia.
Naaser Ahmed Yaseen AbduhDepartment of Chemistry, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi Arabia.ORCID https://orcid.org/0000-0002-7559-1760
Sugarthi SrinivasanDepartment of Physics and Nanotechnology, SRM Institute of Science and Technology, Kattankulathur 603203, India.
Bistuvalli Chandrashekara RevannasidappaDepartment of Pharmaceutical Chemistry, NGSM Institute of Pharmaceutical Sciences of Nitte - Deemed to be University, Paneer, Deralakatte, Mangalore 575018, Karnataka India.
Vasantha KumarDepartment of P.G. Chemistry, Sri Dharmasthala Manjunatheshwara College (Autonomous), Ujire 574240, India.
Kalaiarasi ChinnasamyMolecular Biophysics Unit, Indian Institute of Science, Bangalore 560 012, India.
Sanmargam AravindhanDepartment of Physics, Presidency College (Autonomous), University of Madras, Chennai 600 005, India.
Madan Kumar ShankarDepartment of Chemistry-BMC, University of Uppsala, Husargatan 3, Uppsala 75237, Sweden.ORCID https://orcid.org/0000-0002-7944-1081

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A crucial role in the regulation of DNA replication is played by the highly conserved CDC kinase. The CDC7 kinase could serve as a target for therapeutic intervention in cancer. The primary heterocyclic substance is pyrazole, and its derivatives offer great potential as treatments for cancer cell lines. Here, we synthesized the two pyrazole derivatives: 4-(2-(4-chlorophenyl)hydrazinyl)-5-methyl-2-tosyl-1H-pyrazol-3(2H)-one (PYRA-1) and 4-(2-(2,4-difluorophenyl)hydrazinyl)-5-methyl-2-tosyl-1H-pyrazol-3(2H)-one (PYRA-2). The structural confirmation of both the compounds at the three-dimensional level is characterized using single crystal X-ray diffraction and density functional theory. Furthermore, the

Identifiers

PMID38107948
PMCPMC10719926

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.