Efficient Protocol for Novel Hybrid Pyrimidines Synthesis: Antiproliferative Activity, DFT Analyses, and Molecular Docking Studies.

Ibrahim O Althobaiti, Mjd Saleh Morezeq Alserhani, Wael A A Arafa, Amira A Ghoneim, Modather F Hussein, Hamada Mohamed Ibrahim, Asmaa K Mourad

Open access · goldAbstract read

PubMed Full text at PMC Publisher

In one paragraph

Article in ACS omega, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it

0cells of the map it votes in

2citing papers in PubMed

1.3field-weighted citation impact, top 21% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 9 citations in OpenAlex.

Rational Design, Synthesis, Biological Evaluation, and In Silico Study of N-Cinnamamide/Benzamide-(4-(Substituted Phenyl)-6-(4-Cyclohexylphenyl)pyrimidin-2-Yl) Derivatives as EGFR Inhibitors Targeting EGFRChemical biology & drug design · 2026
Article
A review on pyrimidine-based pharmacophore as a template for the development of hybrid drugs with anticancer potential.Molecular diversity · 2025
Review

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Ibrahim O AlthobaitiChemistry Department, College of Science and Arts, Jouf University, Gurayat 77217, Saudi Arabia.

Mjd Saleh Morezeq AlserhaniChemistry Department, College of Science, Jouf University, Sakaka 72341, Aljouf, Saudi Arabia.

Wael A A ArafaChemistry Department, College of Science, Jouf University, Sakaka 72341, Aljouf, Saudi Arabia.ORCID https://orcid.org/0000-0002-9288-4143

Amira A GhoneimChemistry Department, College of Science, Jouf University, Sakaka 72341, Aljouf, Saudi Arabia.ORCID https://orcid.org/0000-0003-0194-5017

Modather F HusseinChemistry Department, College of Science, Jouf University, Sakaka 72341, Aljouf, Saudi Arabia.

Hamada Mohamed IbrahimChemistry Department, Faculty of Science, Fayoum University, P.O. Box 63514 Fayoum, Egypt.ORCID https://orcid.org/0000-0001-8355-2676

Asmaa K MouradChemistry Department, Faculty of Science, Fayoum University, P.O. Box 63514 Fayoum, Egypt.

Jouf University · SAFayoum University · EGAl-Azhar University · EGZagazig University · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

An efficient, microwave/ultrasound-irradiated synthesis of novel chromenopyrimidines has been established. 2-Amino-5-oxo-4-(thiophen-2-yl)-5,6,7,8-tetrahydro-4

Identifiers

PMID38107937

DOI10.1021/acsomega.3c07434

PMCPMC10720285

OpenAlexW4389235244

What OpenQuestion holds

Textmetadata

LicenceCC BY-NC-ND

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.