ArticleFrontiers in microbiology2023
Oral microbiome alterations in epilepsy and after seizure control.
Article in Frontiers in microbiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- A study on oral microbiome characteristics and differences in epilepsy adults with depressive symptoms based on 16S rRNA sequencing.Frontiers in microbiology · 2026Article
- Human oral microbiome and its influence on mental health and brain disorders.AIMS microbiology · 2025Review
- Causal relationship between oral microbiota and epilepsy risk: Evidence from Mendelian randomization analysis in East Asians.Epilepsia open · 2024Article
- A long journey to treat epilepsy with the gut microbiota.Frontiers in cellular neuroscience · 2024Review
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Authors and funding
11 authors.
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Abstract
Background: The existing diagnostic methods of epilepsy such as history collection and electroencephalogram have great limitations in practice, so more reliable and less difficult diagnostic methods are needed. Methods: By characterizing oral microbiota in patients diagnosed with epilepsy (EPs) and patients whose seizures were under control (EPRs), we sought to discover biomarkers for different disease states. 16S rRNA gene sequencing was performed on 480 tongue swabs [157 EPs, 22 EPRs, and 301 healthy controls (HCs)]. Results: Compared with normal individuals, patients with epilepsy exhibit increased alpha diversity in their oral microbiota, and the oral microbial communities of the two groups demonstrate significant beta diversity differences. EPs exhibit a significant increase in the abundance of 26 genera, including Conclusion: This study describes the characterization of the oral microbiome in EP and EPR and demonstrates the potential of the specific microbiome as a non-invasive diagnostic tool for epilepsy.
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