ArticleFrontiers in neurology2023
The predictive validity of a Brain Care Score for dementia and stroke: data from the UK Biobank cohort.
Article in Frontiers in neurology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 29 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed, 40 citations in OpenAlex.
- Association of baseline brain care score with the incidence of age-related eye diseases.Eye (London, England) · 2026Article
- Menopause and neurological disorders: a roadmap for research.Nature reviews. Neurology · 2026Review
- Brain Health and Traumatic Brain Injury (TBI): Relationship Between Brain Care Score and Disability in Subacute-Long Term TBI.American journal of lifestyle medicine · 2026Article
- Review
- The Saga of Late-Onset Unexplained Epilepsy.Epilepsy currents · 2026Review
- Association Between Brain Care Score and Cognitive Performance: Findings From a Community-Based Cohort in Singapore.Brain and behavior · 2026Article
- Development and validation of the LateDem-Risk score to predict dementia incidence in the InveCe.Ab and Trelong Italian cohorts.Scientific reports · 2026Article
- A community-based model for multimodal brain-health screening and Alzheimer's disease and related dementia risk prediction in mid-sized cities and surrounding rural communities: a mixed-methods evaluation.Innovation in aging · 2026Article
- Implementing brain health strategies in primary care: methods and baseline findings from the BHAM registry.Archives of public health = Archives belges de sante publique · 2025Article
- Younger adult women who had a stroke or at high stroke risk: Exploration of their experiences and needs.Qualitative research in medicine & healthcare · 2025Article
- U.S. public perceptions on whether risk of dementia and stroke can be modified through maintaining or changing lifestyle.BMC public health · 2025Article
- Depression in older adults with epilepsy: Pathophysiology and management considerations.Epilepsy & behavior : E&B · 2025Review
- Investigating the trivariate reciprocal longitudinal relationships between purpose, loneliness, and cognitive function.The journals of gerontology. Series B, Psychological sciences and social sciences · 2025Article
- Assocation Between a Brain Care Score Derived from Participant Responses and Incident Stroke from the COSMOS Study.American journal of lifestyle medicine · 2025Article
- [INVADE: a real-life primary care long-term intervention program for brain health - results from 2013 to 2020].Gesundheitswesen (Bundesverband der Arzte des Offentlichen Gesundheitsdienstes (Germany)) · 2025Article
- Brain health: a new concept to the neurologist - an initiative of the Lifestyle Medicine Commission of the Brazilian Academy of Neurology.Arquivos de neuro-psiquiatria · 2025Review
- Association between physical activity patterns and the risk of stroke phenotypes: an accelerometer-based prospective cohort study from the UK Biobank.BMC public health · 2025Article
- Association of Leucocyte Telomere Length With Stroke, Dementia, and Late-Life Depression: The Role of Modifiable Risk Factors.Neurology · 2025Article
- Use of the Brain Care Score to Estimate the Risk of Incident Cerebrovascular Events in Middle-Aged Women.Neurology · 2025Article
- Lifestyle Knowledge and Behavior Among Stroke and High-Risk Younger Adult Patients Through Sex, Age and Stroke Status Differences: A Cross-Sectional Study.American journal of lifestyle medicine · 2025Article
Corrections and comments
- Erratum issued
Authors and funding
30 authors at 10 institutions in 4 countries.
Funding
Abstract
Introduction: The 21-point Brain Care Score (BCS) was developed through a modified Delphi process in partnership with practitioners and patients to promote behavior changes and lifestyle choices in order to sustainably reduce the risk of dementia and stroke. We aimed to assess the associations of the BCS with risk of incident dementia and stroke. Methods: The BCS was derived from the United Kingdom Biobank (UKB) baseline evaluation for participants aged 40-69 years, recruited between 2006-2010. Associations of BCS and risk of subsequent incident dementia and stroke were estimated using Cox proportional hazard regressions, adjusted for sex assigned at birth and stratified by age groups at baseline. Results: The BCS (median: 12; IQR:11-14) was derived for 398,990 UKB participants (mean age: 57; females: 54%). There were 5,354 incident cases of dementia and 7,259 incident cases of stroke recorded during a median follow-up of 12.5 years. A five-point higher BCS at baseline was associated with a 59% (95%CI: 40-72%) lower risk of dementia among participants aged <50. Among those aged 50-59, the figure was 32% (95%CI: 20-42%) and 8% (95%CI: 2-14%) for those aged >59 years. A five-point higher BCS was associated with a 48% (95%CI: 39-56%) lower risk of stroke among participants aged <50, 52% (95%CI, 47-56%) among those aged 50-59, and 33% (95%CI, 29-37%) among those aged >59. Discussion: The BCS has clinically relevant and statistically significant associations with risk of dementia and stroke in approximately 0.4 million UK people. Future research includes investigating the feasibility, adaptability and implementation of the BCS for patients and providers worldwide.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.