Evidence map›Paper›PMID 38107615›Full record

ArticleFrontiers in bioengineering and biotechnology2023

The effect of nodal connectivity and strut density within stochastic titanium scaffolds on osteogenesis.

Stylianos Kechagias, Konstantinos Theodoridis, Joseph Broomfield, Kenny Malpartida-Cardenas, Ruth Reid, Pantelis Georgiou, Richard J van Arkel, Jonathan R T Jeffers

Abstract read
In one paragraph

Article in Frontiers in bioengineering and biotechnology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Characterization of a Novel Col1a1Calcified tissue international · 2025
    Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Stylianos KechagiasDepartment of Mechanical Engineering, Imperial College London, London, United Kingdom.
Konstantinos TheodoridisDepartment of Mechanical Engineering, Imperial College London, London, United Kingdom.
Joseph Broomfield *Centre for Bio Inspired Technology, Department of Electrical and Electronic Engineering, Imperial College London, London, United Kingdom.
Kenny Malpartida-Cardenas *Centre for Bio Inspired Technology, Department of Electrical and Electronic Engineering, Imperial College London, London, United Kingdom.
Ruth Reid *Centre for Bio Inspired Technology, Department of Electrical and Electronic Engineering, Imperial College London, London, United Kingdom.
Pantelis GeorgiouCentre for Bio Inspired Technology, Department of Electrical and Electronic Engineering, Imperial College London, London, United Kingdom.
Richard J van ArkelDepartment of Mechanical Engineering, Imperial College London, London, United Kingdom.
Jonathan R T JeffersDepartment of Mechanical Engineering, Imperial College London, London, United Kingdom.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Modern orthopaedic implants use lattice structures that act as 3D scaffolds to enhance bone growth into and around implants. Stochastic scaffolds are of particular interest as they mimic the architecture of trabecular bone and can combine isotropic properties and adjustable structure. The existing research mainly concentrates on controlling the mechanical and biological performance of periodic lattices by adjusting pore size and shape. Still, less is known on how we can control the performance of stochastic lattices through their design parameters: nodal connectivity, strut density and strut thickness. To elucidate this, four lattice structures were evaluated with varied strut densities and connectivity, hence different local geometry and mechanical properties: low apparent modulus, high apparent modulus, and two with near-identical modulus. Pre-osteoblast murine cells were seeded on scaffolds and cultured

Indexed as

3D cell cultureadditive manufacturingbone scaffoldsorthopaedic implantsosteoblast differentiationtrabecular bone

Identifiers

PMID38107615
PMCPMC10721980

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.